Resolution of Inflammation

  • Christopher Haslett
  • Peter Henson


Inflammation is a highly effective component of the innate response of the body to infection or injury. The inflammatory response is an important consequence of injury and one that normally leads to repair and restoration of function. Indeed, until the last two or three decades, inflammation was perceived as an entirely beneficial host response. From his experiences on the battle fields of Europe, John Hunter stated “Inflammation is itself not to be considered as a disease but as a salutary operation consequent either to some violence or to some disease” and Eli Metchnikoff (1968), the father of modern inflammatory cell biology, emphasized this concept in his work. The clear-cut implication of these observations is the close connection between the inflammatory process and repair. It has become apparent, however, that inflammation can contribute to the pathogenesis of a large number of diseases. For example, neutrophil infiltration, if not controlled, contributes to tissue injury and necrosis. A relationship between inflammation and scarring has been recognized in such disorders as adult respiratory distress syndrome, fibrosing alveolitis in the lung, hepatitic cirrhosis, glomerulonephritis, as well as infected cutaneous wounds. Extensive scarring or fibrosis of any organ can cause catastrophic loss of function of that organ.


Inflame Site Neutrophil Apoptosis Neutrophil Influx Major Basic Protein Apoptotic Neutrophil 
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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Christopher Haslett
    • 1
  • Peter Henson
    • 2
  1. 1.Respiratory Medicine Unit, Department of MedicineUniversity of Edinburgh, Royal InfirmaryEdinburghScotland
  2. 2.Departments of Medicine and PathologyNational Jewish Center for Immunology and Respiratory MedicineDenverUSA

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