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Fetal Wound Healing and the Development of Antiscarring Therapies for Adult Wound Healing

  • Chapter
The Molecular and Cellular Biology of Wound Repair

Abstract

Scarring is an important clinical problem, often resulting in adverse effects on function and growth as well as an undesirable cosmetic appearance. Adult wound healing is characterized by acute inflammation, contraction, and collagen deposition, responses likely to have been optimized for rapid wound closure and minimizing infection. Similar processes may also result in fibrotic diseases that are common in many areas of medicine and surgery. Abdominal surgery often leads to intraperitoneal fibrous adhesions, while fibrotic retinopathy in diabetes, pulmonary fibrosis, and hepatic cirrhosis are significant medical problems. A major medical objective is therefore the reduction, and ideally the prevention, of scarring.

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  1. School of Biological Sciences, University of Manchester, Manchester, M13 9PT, England

    R. L. McCallion & M. W. J. Ferguson

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  1. R. L. McCallion
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  1. Department of Dermatology, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, New York, 11794-8165, USA

    Richard A. F. Clark

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McCallion, R.L., Ferguson, M.W.J. (1988). Fetal Wound Healing and the Development of Antiscarring Therapies for Adult Wound Healing. In: Clark, R.A.F. (eds) The Molecular and Cellular Biology of Wound Repair. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0185-9_18

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