Fetal Wound Healing and the Development of Antiscarring Therapies for Adult Wound Healing

  • R. L. McCallion
  • M. W. J. Ferguson


Scarring is an important clinical problem, often resulting in adverse effects on function and growth as well as an undesirable cosmetic appearance. Adult wound healing is characterized by acute inflammation, contraction, and collagen deposition, responses likely to have been optimized for rapid wound closure and minimizing infection. Similar processes may also result in fibrotic diseases that are common in many areas of medicine and surgery. Abdominal surgery often leads to intraperitoneal fibrous adhesions, while fibrotic retinopathy in diabetes, pulmonary fibrosis, and hepatic cirrhosis are significant medical problems. A major medical objective is therefore the reduction, and ideally the prevention, of scarring.


Hyaluronic Acid Amniotic Fluid Wound Repair Wound Contraction Fetal Fibroblast 
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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • R. L. McCallion
    • 1
  • M. W. J. Ferguson
    • 1
  1. 1.School of Biological SciencesUniversity of ManchesterManchesterEngland

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