The Dermal-Epidermal Basement Membrane Zone in Cutaneous Wound Healing

  • Jouni Uitto
  • Alain Mauviel
  • John McGrath


The formation and repair of the functional extracellular matrix as part of the wound healing process requires coordinate expression of a repertoire of related and unrelated genes, including those encoding matrix proteins and proteolytic and regulatory enzymes. In addition, the formation of a functionally organized basement membrane between the epidermis and the dermis is essential for the integrity of the skin to allow its function as a protective organ. This chapter will highlight the recent progress made in understanding the biochemistry and molecular biology of the cutaneous basement membrane zone.


Bullous Pemphigoid Epidermolysis Bullosa Chloramphenicol Acetyl Transferase Papillary Dermis Basal Keratinocytes 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Jouni Uitto
    • 1
  • Alain Mauviel
    • 1
  • John McGrath
    • 1
  1. 1.Departments of Dermatology and Cutaneous Biology, and Biochemistry and Molecular Biology, Jefferson Medical College, and Section of Molecular Dermatology, Jefferson Institute of Molecular MedicineThomas Jefferson UniversityPhiladelphiaUSA

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