Abstract
Following tissue injury, tissue repair takes place in well-characterized steps. After clot formation, inflammatory cells, essentially mononuclear cells and granulocytes, invade the injured tissue; then, fibroblasts migrate, proliferate, and synthesize extracellular matrix components, participating in the formation of granulation tissue. Finally, following reepithelialization and wound closure, tissue remodeling implicates extracellular matrix degradation, decrease of cellularity, and constitution of the scar.
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Desmoulière, A., Gabbiani, G. (1988). The Role of the Myofibroblast in Wound Healing and Fibrocontractive Diseases. In: Clark, R.A.F. (eds) The Molecular and Cellular Biology of Wound Repair. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0185-9_13
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