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The Role of the Myofibroblast in Wound Healing and Fibrocontractive Diseases

  • Chapter
The Molecular and Cellular Biology of Wound Repair

Abstract

Following tissue injury, tissue repair takes place in well-characterized steps. After clot formation, inflammatory cells, essentially mononuclear cells and granulocytes, invade the injured tissue; then, fibroblasts migrate, proliferate, and synthesize extracellular matrix components, participating in the formation of granulation tissue. Finally, following reepithelialization and wound closure, tissue remodeling implicates extracellular matrix degradation, decrease of cellularity, and constitution of the scar.

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Authors and Affiliations

  1. Department of Pathology, University of Geneva, 1211 Geneva 4, Switzerland

    Alexis Desmoulière

  2. Institut Pasteur de Lyon, CNRS-URA 1459, 69365, Lyon cedex 7, France

    Alexis Desmoulière

  3. Department of Pathology, University of Geneva, 1211, Geneva 4, Switzerland

    Giulio Gabbiani

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  1. Alexis Desmoulière
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  2. Giulio Gabbiani
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  1. Department of Dermatology, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, New York, 11794-8165, USA

    Richard A. F. Clark

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Desmoulière, A., Gabbiani, G. (1988). The Role of the Myofibroblast in Wound Healing and Fibrocontractive Diseases. In: Clark, R.A.F. (eds) The Molecular and Cellular Biology of Wound Repair. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0185-9_13

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