Wound Repair

Overview and General Considerations
  • Richard A. F. Clark

Abstract

When tissue loss disrupts normal architecture in higher vertebrate adult animals, the organ fails to regenerate. Instead, repair proceeds as a fibroproliferative response that develops into a fibrotic scar. Thus, the organ is patched rather then restored. Alterations in the normal healing processes produce even less desirable outcomes. For example, when injurious events persist or recur, inflammation is perpetuated, extending tissue damage and repair. In addition, a plethora of pathobiological states, such as diabetes, Cushing’s syndrome, poor arterial perfusion, venous hypertension, poor nutrition, and sepsis, disrupt normal repair processes. Such situations often lead to nonhealing wounds or excessive fibrosis.

Keywords

Hyaluronic Acid Granulation Tissue Wound Repair Fibrin Clot Fibrillar Collagen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Richard A. F. Clark
    • 1
  1. 1.Department of Dermatology, Health Sciences CenterState University of New York at Stony BrookStony BrookUSA

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