Taurine 2 pp 589-595 | Cite as

Effects of Taurine on Calcium in Platelets and their Aggregation

  • E. P. Elizarova
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 403)

Abstract

Taurine concentrations are 400-fold greater in platelets than in plasma1, 5. The role of taurine in platelets has not been elucidated. For cardiologists, platelet taurine content is likely to have diagnostic value, since a decrease in taurine concentration in these cells indirectly reflects changes in taurine level in body tissues in general and in heart in particular11. Paasonen et al. 12 have reported that the taurine level in patients with hypertension does not differ from control values but increases in patients with myocardial infarction. In platelets, taurine transport decreases both in hypertension and in cardiovascular failure9. Marked losses of taurine from animals or humans affects the functional state of not only such organs as heart13 and retina8 but also of platelets. Taurine is known to model Ca2+ responses to PAF3. Taurine can inhibit PAF-induced aggregation of guinea pig platelets and aggregation of human platelets induced by ADP, serotonin and epinephrine2. Hayes et al. 9 reported the interrelation of taurine status and platelet aggregation in cat. They discovered that marked loss of taurine from platelets make them more sensitive to aggregation. These authors assume that this effect can be mediated via changes in GSH and altered thromboxane liberation. We suppose that this effect of taurine is not its only platelet action. Taurine may possess a homeostatic action that is revealed in certain pathological conditions. For this reason we have studied taurine effects in cells obtained from donors with different rhythm disturbances.

Keywords

Platelet Aggregation Human Platelet Platelet Response Platelet Suspension Taurine Level 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Ahtee, L., Boullin, D.J., and Paasonen, M.K. 1974, Transport of taurine by normal human blood platelets, Br.J.Pharm. 52:245–251.CrossRefGoogle Scholar
  2. 2.
    Almazov, V.A., Gurevich, V.S., Mikhailova, I.A., and Strelstova, E.N. 1986, Effect of taurine on Ca, Mg-ATPase activity and platelet aggregation in man, Exp.Biol.Med. 100:1314–1317.Google Scholar
  3. 3.
    Atahanov, S.E. and Elizarova, E.P. 1992, Modulation of receptor-dependent increase of calcium ions in human platelets by taurine, Arzneimittelforschung, 42:1311–1313.Google Scholar
  4. 4.
    Avdonin, P.V., Menchikov, M.Y., Orlov, S.N., Pokudin, N.I., and Tkachuk, V.A. 1985, Mechanisms of elevation of Ca2+ in platelet cytoplasm induced by aggregation factors, Biochemistry (Russ.), 50:1055–1062.Google Scholar
  5. 5.
    Frendo, J., Koj, A., and Zgliczynski, J.M. 1959, Taurine in human blood platelets, Nature, 183:685–686.CrossRefGoogle Scholar
  6. 6.
    Gabbasov, Z.A., Popov, E.G., Gavrilov, I.Y. and Pozin, A.Y. 1989, Anew methodological approach to in vitro study aggregation, Byull.Eksp.Biol. N 10:437–440.Google Scholar
  7. 7.
    Gabbasov, Z.A., Popov, E.G., Gavrilov, I.Y. and Pozin, A.Y. 1989, Platelet aggregation: the use optical density fluctuations to study microaggregate formation in platelet suspension, Thromb.Res. 54:215–223.CrossRefGoogle Scholar
  8. 8.
    Hayes, K.C., Carey, R.E., and Schmidt, S.Y. 1975, Retinal degeneration associated with taurine deficiency in the cat, Science, 188:949–951.CrossRefGoogle Scholar
  9. 9.
    Hayes, K.C., Pronczuk, A., Addesa, A.E., and Stephan, Z.F. 1989, Taurine modulates platelet aggregation in cats and humans, Am.J.Clin.Nutr., 49:1211–1216.Google Scholar
  10. 10.
    Kulakowski, E.C., Maturo, J., and Schaffer, S.W. 1978, The identification of taurine receptors from rat heart sarcolemma, Biochem.Biophys.Res.Comm., 80:936–941.CrossRefGoogle Scholar
  11. 11.
    Orlova, T.R., Yakushkin, V.V., and Elizarova, E.P. 1990, Taurine content in blood and myocardium of rabbits with experimental heart failure, Physiol.J., 35:3–7.Google Scholar
  12. 12.
    Paasonen, M.K., Penttila, O., Himberg, J.J., and Solatunturi, E. 1980, Platelet taurine in patients with arterial hypertension, myocardial failure or infarction, Acta Med.Scand. 642(Suppl.):79–84.Google Scholar
  13. 13.
    Pion, P.D., Kittleson, M.D., Rogers, Q.R., and Morris, J.G. 1987, Myocardial failure in cats associated with low plasma taurine: a reversible cardiomyopathy, Science, 237:764–768.CrossRefGoogle Scholar
  14. 14.
    Tsein, R.Y., Pozzan, T., and Rink, T.J. 1982, Calcium homeostasis in intact lymphocytes: Cytoplasmic free calcium monitored with a new intracellularly trapped fluorescent indicator, J.Cell.Biol. 94:325–334.CrossRefGoogle Scholar
  15. 15.
    Yurenev, A., Balyakina, E., Dubov, P., Popov, E., Gabbasov, A.S. and Ataschanov, S. 1992, Laser aggregometry in hypertensives with and without left ventricular hypertrophy, Am.J.Hypert. 5:25a.Google Scholar
  16. 16.
    Yurenev, A.V., DeQuabbro, Dulov, P., Ostroumov, N., Niculin, I., Konyaeva, E., Balyakina, E., Atakhanov, S., Kosenka, A., Popov, E., Gabbasov, Z., and Gulyaev, V. 1992, Silent myocardial ischemia in patients with essential hypertension, AmJ.Hypert. 5:169s–174s.Google Scholar

Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • E. P. Elizarova
    • 1
  1. 1.Cardiology Research CenterMoscowRussia

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