Taurine 2 pp 583-588 | Cite as

First Experiments in Taurine Administration for Diabetes Mellitus

The Effect on Erythrocyte Membranes
  • E. P. Elizarova
  • L. V. Nedosugova
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 403)


The hypoglycemic effect of taurine was discovered in 1935 by Ackerman and Heisen1. Dokshina et al. 3 found later in the seventies that taurine increased glucose consumption in diaphragm tissue and glycogen accumulation by leukocytes and liver. Kulakowski and Maturo7 in the eighties also described insulin-like activity of taurine. Lampson, Kramer and Schaffer5 found that taurine potentiated the effect of insulin and influenced activity of phosphorylase a and glycogen synthase I.


Erythrocyte Ghost Taurine Treatment Sarcolemmal Vesicle Phospholipid Methylation Tris Phosphate Buffer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Ackermann, D. and Heinsen, H.A. 1935, Über die physiologische Wirkung des Asterubins und anderer zum Teil neu dargestellter, schwefelhaltiger Guanidinderivative, Z.Physiol.Chem. 235:115–121.CrossRefGoogle Scholar
  2. 2.
    Biostein, R. and Chu, L. 1977, Sidedness of (sodium, potassium)-adenosine triphosphate of inside-out red cell membrane vesicles interaction with potassium, J.Biol.Chem. 252:3036–3043.Google Scholar
  3. 3.
    Dokshina, G.A., Yu-Silaeva, T., and Yartsev, E.I. 1976, Some insulin-like effects of taurine, Vopr.Med.Khim. 22:503–507.Google Scholar
  4. 4.
    Kates, M. 1988, “Techniques of Lipidology: Isolation, Analysis and Identification of Lipids”, Elsevier, Amsterdam.Google Scholar
  5. 5.
    Lampson, W.G., Kramer, J.H., and Schaffer, S.W. 1983, Potentiation of the actions of insulin by taurine, Can.J.Physiol.Pharmacol. 61:457–463.CrossRefGoogle Scholar
  6. 6.
    Lleu, P.-L. and Huxtable, R.J. 1992, Phospholipid methylation and taurine content of synaptosomes from cerebral cortex of developing rat, Neurochem.Int., 21:109–118.CrossRefGoogle Scholar
  7. 7.
    Maturo, J. and Kulakowski, E.C. 1987, Insulin-like activity of taurine, in: “The Biology of Taurine: Methods and Mechanisms”, Huxtable, R.J., Franconi, F. and Giotti, A. eds. Plenum Press, New York, pp. 217–226.Google Scholar
  8. 8.
    McGivney, A., Crews, F.T., Hirata, F., Axelrod, J., and Siraganian, R.R. 1981, Rat basophilic leukemia cells defective in phospholipid methyltransferase enzyme, Ca2+ influx and histamine release: Reconstruction by hybridization, Proc.Natl.Acad.Sci.USA, 78:6176–6180.CrossRefGoogle Scholar
  9. 9.
    Panagia, V., Makino, N., Ganguly, P.K., and Dhalla, N.S. 1987, Inhibition of Na+-Ca2+ exchange in heart sarcolemmal vesicles by phosphatidylethanolamine N-methylation, Eur.J.Biochem. 166:597–603.CrossRefGoogle Scholar
  10. 10.
    Punna, S., Ballard, C., Hamaguchi, T., Azuma, J., and Schaffer, S. 1994, Effect of taurine and methionine on sarcoplasmic reticular Ca2+ transport and phospholipid methyltransferase activity, J.Cardiovasc.Pharmacol. 24:286–292.Google Scholar
  11. 11.
    Steck, T.L. and Kant, J.A. 1974, Preparation of impermeable ghosts and inside-out vesicles from human erythrocyte membranes, in: “Methods in Enzymology, Vol. 31 ”, Fleisner, S. and Parker, L. eds., Academic Press, New York, pp. 172–180.Google Scholar

Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • E. P. Elizarova
    • 1
  • L. V. Nedosugova
    • 1
  1. 1.Cardiology Research CenterMoscowRussia

Personalised recommendations