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Interaction of γ-L-Glutamyltaurine with Kainate-Induced Cyclic Amp Formation in the Rat Hippocampus

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Taurine 2

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 403))

Abstract

γ-L-Glutamyltaurine (LGT) is the most abundant taurine-containing peptide in the CNS19, 31, being located mainly in neurons30. LGT is synthesized by γ-glutamyltransferase (EC 2.3.2.2) and can be degraded to glutamate and taurine by γ-glutamyltransferase or to 5-oxoproline and taurine by γ-glutamylcyclotransferase (EC 2.3.2.4)17, 31. Some intriguing central effects (e. g. anticonflict and antiepileptic actions) of LGT have been reported10, 16. They may be attributed to the interaction of LGT with different steps of glutamatergic neurotransmission32–34.

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Author information

Authors and Affiliations

  1. Tampere Brain Research Center, University of Tampere Medical School, Box 607, FIN-33101, Tampere, Finland

    V. Varga, Réka Janáky, S. S. Oja & Leena Rechardt

  2. Frederic Joliot-Curie National Research Institute for Radiobiology and Radiohygiene, Box 101, H-1775, Budapest, Hungary

    A. Takáts

  3. Department of Clinical Physiology, Tampere University Hospital, Box 2000, FIN-33521, Tampere, Finland

    S. S. Oja

  4. Department of Animal Physiology, Kossuth Lajos University of Sciences, Box 18, H-4010, Debrecen, Hungary

    V. Varga & R. Dohovics

Authors
  1. V. Varga
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  2. Réka Janáky
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  4. S. S. Oja
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  6. Leena Rechardt
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Editor information

Editors and Affiliations

  1. University of Arizona, Tucson, Arizona, USA

    Ryan J. Huxtable

  2. Osaka University Osaka, Osaka, Japan

    Junichi Azuma  & Akemichi Baba  & 

  3. Kyoto Prefectural University of Medicine, Kyoto, Japan

    Kinya Kuriyama  & Masao Nakagawa  & 

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© 1996 Springer Science+Business Media New York

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Varga, V., Janáky, R., Takáts, A., Oja, S.S., Dohovics, R., Rechardt, L. (1996). Interaction of γ-L-Glutamyltaurine with Kainate-Induced Cyclic Amp Formation in the Rat Hippocampus. In: Huxtable, R.J., Azuma, J., Kuriyama, K., Nakagawa, M., Baba, A. (eds) Taurine 2. Advances in Experimental Medicine and Biology, vol 403. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0182-8_51

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  • DOI: https://doi.org/10.1007/978-1-4899-0182-8_51

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-0184-2

  • Online ISBN: 978-1-4899-0182-8

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