Abstract
The physiological role of taurine, one of the most abundant free amino acids in the mammalian brain, is still poorly understood. A solid body of electrophysiological studies has demonstrated that taurine application causes neuroinhibitory actions in different regions of the CNS. In this sense, taurine has been shown to reduce the spontaneous neuronal firing, to hyperpolarize the resting membrane potential, to diminish the membrane input resistance and to increase the membrane Cl- conductance in different CNS neurons2, 4, 7, 19, 23, 24. On the basis of these observations, taurine has been proposed as a putative neuroinhibitory transmitter in the CNS. However, because of the lack of selective taurine antagonists, this possibility has not been unambiguously demonstrated so far. In fact, many of the taurine-in-duced neuroinhibitory effects have been shown to be blocked by GABA and/or glycine receptor antagonists4, 7, 20.
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References
Bureau, M.H. and Olsen, R.W. 1991, Taurine acts on a subclass of GABAA receptors in mammalian brain in vitro, Eur. J. Pharmacol, 207:9–16.
Curtis, D.R., Phillis, J.W. and Watkins, J.C. 1961, Actions of amino acids on the isolated hemisected spinal cord of the toad, Br. J. Pharmacol., 16:262–283.
Franconi, F., Martini, F., Stendardi, I., Matucci, R., Zilleti, L. and Giotti, A. 1982, Effect of taurine on calcium levels and contractility in guinea-pig ventricular strips, Biochem. Pharmacol., 31:3181–3185.
Frederickson, R.C.A., Neuss, M., Morzorati, S.L. and McBride, W.J. 1978, A comparison of the inhibitory effects of taurine and GABA on identified Purkinje cell and other neurons in the cerebellar cortex of the rat, Brain Res., 145:117–126.
Galarreta, M., Bustamente, J., Martín del Río, R. and Solís, J.M. 1996, Taurine induces a long-lasting increase of synaptic efficacy and axon excitability in the hippocampus, J.Neurosci. 16:92–102.
Gruener, R., Bryant, H., Markovitz, D., Huxtable, R.J. and Bressler, R. 1976, Ionic actions of taurine on nerve and muscle membranes: electrophyisologic studies, in: “Taurine”, Huxtable, R.J. and Barbeau A. (Eds.), Raven Press, New York, pp. 225–242.
Häusser, M.A., Yung, W.H. and Lacey, M.G. 1992, Taurine and glycine activate the same Cl- conductance in the substantia nigra dopamine neurons, Brain Res., 571:103–108.
Huxtable, R.J. 1989, Taurine in the central nervous system and the mammalian actions of taurine, Prog. Neurobiol, 32:471–533.
Huxtable, R.J. and Sebring, L.A. 1986, Towards a unifying theory for the action of taurine, Trends Pharmac.Sci., 7:481–485.
Kamisaki, Y., Maeda, K., Ishimura, M., Omura, H. and Itoh, T. 1993, Effects of taurine on depolarization-evoked release of amino acids from rat cortical synaptosomes, Brain Res., 627:181–185.
Kamiya, H. and Zucker, R.S. 1994, Residual Ca2+ and short-term synaptic plasticity, Nature, 371:603–606.
Kontro, P. and Oja, S.S. 1981, Hypotaurine transport in brain slices: comparison with taurine and GABA, Neurochem. Res., 6:1179–1191.
Kontro, P. and Oja, S.S. 1983, Binding of taurine to brain synaptic membranes. In: “CNS Receptors: From Molecular Pharmacology to Behavior”, Mandel, P. and DeFeudis, F.V. (Eds.), Raven Press, New York, pp. 23–34.
Lerma, J., Herranz, A.S., Herreras, O., Abraira, V. and Martín del Río, R. 1986, In vivo determination of extracellular concentrations of amino acids in the rat hippocampus. A method based on brain dialysis and computerized analysis, Brain Res., 384:145–155.
Li, Y.-P. and Lombardini, J.B. 1991, Taurine inhibits protein kinase C-catalyzed phosphorylation of specific proteins in a rat cortical P2 fraction, J. Neurochem., 56:1747–1753.
Liu, Q.-R., López-Corcuera, B., Nelson, H., Mandiyan, S. and Nelson, N. 1992, Cloning and expression of cDNA encoding the transporter of taurine and β-alanine in mouse brain, Proc. Natl. Acad. Sci. USA, 89:12145–12149.
Malminen, O. and Kontro, P. 1986, Modulation of the GABA-benzodiazepine receptor complex by taurine in rat brain membranes, Neurochem. Res., 11:85–94.
Namima, M., Okamoto, K. and Sakai, Y. 1983, Modulatory action of taurine on the release of GABA in cerebellar slices of guinea pig, J. Neurochem., 40:1–9.
Okamoto, K., Kimura, H. and Sakai, Y. 1983, Effects of taurine and GABA on Ca spikes and Na spikes in cerebellar Purkinje cells in vitro: intrasomatic study, Brain Res., 260:249–259.
Okamoto, K. and Sakai, Y. 1981, Inhibitory actions of taurocyamine, hypotaurine, homotaurine, taurine and GABA on spike discharges of Purkinje cells, and localization of sensitive sites, in guinea pig cerebellar slices, Brain Res., 206:371–386.
Pasantes-Morales, H. and Gamboa, A. 1980, Effect of taurine on 45Ca2+ accumulation in rat brain synaptosomes, J. Neurochem., 34:244–246.
Sebring, L.A. and Huxtable, R.J. 1985, Taurine modulation of calcium binding to cardiac sarcolemma, J. Pharmacol. Exp. Therap., 232:445–451.
Taber, K.H., Lin, C.-T., Liu, J.-W., Thalmann, R.H. and Wu, J.-Y. 1986, Taurine in hippocampus: localization and postsynaptic action, Brain Res., 386:113–121.
Zeise, M. 1985, Taurine on hippocampal slices: comparison to GABA and glycine, and antagonism by 4-aminopyridine, in: “Taurine: Biological Actions and Clinical Perspectives”, Oja, S.S., Ahtee, L., Kontro, P. and Paasonen, M.K., (Eds.), Alan R. Liss, Inc., pp. 281-287.
Zucker, R.S. 1989, Short-term synaptic plasticity, Ann. Rev. Neurosci., 12:13–31.
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Galarreta, M., Bustamante, J., del Río, R.M., Solís, J.M. (1996). A New Neuromodulatory Action of Taurine: Long-Lasting Increase of Synaptic Potentials. In: Huxtable, R.J., Azuma, J., Kuriyama, K., Nakagawa, M., Baba, A. (eds) Taurine 2. Advances in Experimental Medicine and Biology, vol 403. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0182-8_50
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