Taurine 2 pp 435-444 | Cite as

Distributions of Taurine, Glutamate, and Glutamate Receptors during Post-Natal Development and Plasticity in the Rat Brain

  • Kathy R. Magnusson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 403)


Taurine and glutamate both play roles in the development of the mammalian nervous system10, 17, 46. Taurine is involved in granule cell migration in the developing cerebellum37, 47, 48, 50 and is in high concentrations within axons of the optic tract before and during the establishment and refinement of synapses12, 34, 45. Glutamate, and one subtype of glutamate receptor, the N-methyl-D-aspartate (NMDA) receptor, have also been shown to be involved in the process of granule cell migration in the cerebellum10. NMDA receptors also appear to influence neurite outgrowth and survival of these granule cells2, 32, 35. In the hippocampus, glutamate promotes branching of neurites and synapse formation3, 26, 28. These studies indicate that there is an optimal range of glutamate concentration during development that promotes complexity, but higher concentrations are lethal to the developing neuron26. An inhibitory transmitter, γ-aminobutyric acid (GABA), is able to reduce the glutamate-in-duced regression of dendrites in culture25, suggesting that a modulatory influence is necessary during development to encourage optimal growth, while preventing excitotoxicity.


Purkinje Cell Glutamate Receptor Granule Cell Dentate Gyrus Entorhinal Cortex 
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  1. 1.
    Altman, J. 1972, Postnatal development of the cerebellar cortex in the rat. II. Phases in the maturation of Purkinje cells and of the molecular layer, J. Comp. Neurol. 145:399–464.CrossRefGoogle Scholar
  2. 2.
    Balazs, R., Jorgensen, O.S. and Hack, N. 1988, Stimulation of the N-methyl-D-aspartate receptor has a trophic effect on differentiating cerebellar granule cells, Neuroscience, 27:437–451.CrossRefGoogle Scholar
  3. 3.
    Brewer, G.J. and Cotman, C.W. 1989, NMDA receptor regulation of neuronal morphology in cultured hippocampal neurons, Neurosci. Lett., 99:268–273.CrossRefGoogle Scholar
  4. 4.
    Choi, D.W. 1987, Ionic dependence of glutamate neurotoxicity, J. Neurosci. 7:369–379.Google Scholar
  5. 5.
    Collins, R.C. 1986, Selective vulnerability of brain: New insights from the excitatory synapse, Metab. Brain Dis. 1:231–240.CrossRefGoogle Scholar
  6. 6.
    Cotman, C.W., Matthews, D.A., Taylor, D. and Lynch, G. 1973, Synaptic rearrangement in the dentate gyrus: Histochemical evidence of adjustments after lesions in immature and adult rats, Proc. Natl. Acad. Sci. USA, 70:3473–3477.CrossRefGoogle Scholar
  7. 7.
    Dure, L.S., Young, A.B. and Penney, J.B. 1991, Excitatory amino acid binding sites in the caudate nucleus and frontal cortex of Huntington’s disease, Ann. Neurol., 30:785–793.CrossRefGoogle Scholar
  8. 8.
    French, E.D., Vezzani, A., Whetsell Jr., W.O. and Schwarcz. R. 1986, Antiexcitotoxic actions of taurine in the rat hippocampus studied in vivo and in vitro, Adv. Exp. Med. Biol. 203:349–362.CrossRefGoogle Scholar
  9. 9.
    Grandes, P. and Streit, P. 1991, Effect of perforant path lesion on pattern of glutamate-like immunoreactivity in rat dentate gyrus, Neuroscience, 41:390–400.CrossRefGoogle Scholar
  10. 10.
    Komuro, H. and Rakic, P. 1993, Modulation of neuronal migration by NMDA receptors, Science, 260:95–97.CrossRefGoogle Scholar
  11. 11.
    Kontro, P. and Oja, S.S. 1989, Release of taurine and GABA from cerebellar slices from developing and adult mice, Neuroscience, 29:413–423.CrossRefGoogle Scholar
  12. 12.
    Lake, N. 1992, Taurine, GABA and GFAP immunoreactivity in the developing and adult rat optic nerve, Brain Res., 596:124–132.CrossRefGoogle Scholar
  13. 13.
    Lehmann, A., Hagberg, H. and Hamberger, A. 1984, A role for taurine in the maintenance of homeostasis in the central nervous system during hyperexcitation, Neurosci.Lett, 52:341–346.CrossRefGoogle Scholar
  14. 14.
    Lehmann, A., Hagberg, H., Lazarewicz, J.W., Jacobson, I. and Hamberger, A. 1986, Alterations in extracellular amino acids and Ca2+ following excitotoxin administration and during status epilepticus, Adv. Exp. Med. Biol., 203:363–373.CrossRefGoogle Scholar
  15. 15.
    Lehmann, A., Isacsson, H. and Hamberger, A. 1983, Effects of in vivo administration of kainic acid on the extracellular amino acid pool in the rabbit hippocampus, J. Neurochem. 40:1314–1320.CrossRefGoogle Scholar
  16. 16.
    Lehmann, A., Lazarewicz, J.W. and Zeise, M. 1985, N-Methylaspartate-evoked liberation of taurine and phosphonoethanolamine in vivo: Site of release, J. Neurochem., 45:1172–1177.CrossRefGoogle Scholar
  17. 17.
    Lipton, S.A. and Kater, S.B. 1989, Neurotransmitter regulation of neuronal outgrowth, plasticity and survival, Trends Neurosci. 12:265–270.CrossRefGoogle Scholar
  18. 18.
    Lu, P., Schuller-Levis, G. and Sturman, J.A. 1991, Distribution of taurine-like immunoreactivity in cerebellum of kittens from taurine-supplemented and taurine-deficient mothers, Int. J. Dev. Neurosci. 9:621–629.CrossRefGoogle Scholar
  19. 19.
    Lynch, G., Deadwyler, S. and Cotman, C. 1973, Postlesion axonal growth produces permanent functional connections, Science 180:1364–1366.CrossRefGoogle Scholar
  20. 20.
    Magnusson, K.R., Clements, J.R., Wu, J.-Y. and Beitz, A.J. 1989, Colocalization of taurine-and cysteine sulfinic acid decarboxylase-like immunoreactivity in the hippocampus of the rat, Synapse, 4:55–69.CrossRefGoogle Scholar
  21. 21.
    Magnusson, K.R. and Cotman, C.W. 1993, Age-related changes in excitatory amino acid receptors in two mouse strains, Neurobiol. Aging, 14:197–206.CrossRefGoogle Scholar
  22. 22.
    Magnusson, K.R., Koerner, J.F., Larson, A.A., Smullin, D.H., Skilling, S.R. and Beitz, A.J. 1991, NMDA-, kainate-and quisqualate-stimulated release of taurine from electrophysiologically-monitored rat hippocampal slices, Brain Res., 549:1–8.CrossRefGoogle Scholar
  23. 23.
    Magnusson, K.R., Madl, J.E., Clements, J.R., Wu, J., Larson, A.A. and Beitz, A.J. 1988, Colocalization of taurine-and cysteine sulfinic acid decarboxylase-like immunoreactivity in the cerebellum of the rat with monoclonal antibodies against taurine, J. Neurosci., 8:4551–4564.Google Scholar
  24. 24.
    Matthews, D.A., Cotman, C. and Lynch, G. 1976, An electron microscopic study of lesion-induced synaptogenesis in the dentate gyrus of the adult rat. I. Magnitude and time course of degeneration, Brain Res. 115:1–21.CrossRefGoogle Scholar
  25. 25.
    Mattson, M.P. and Kater, S.B. 1989, Excitatory and inhibitory neurotransmitters in the generation and degeneration of hippocampal neuroarchitecture, Brain Res., 478:337–348.CrossRefGoogle Scholar
  26. 26.
    Mattson, M.P., Lee, R.E., Adams, M.E., Guthrie, PB. and Kater, S.B. 1988, Interactions between entorhinal axons and target hippocampal neurons: A role for glutamate in the development of hippocampal circuitry, Neuron, 1:865–876.CrossRefGoogle Scholar
  27. 27.
    McDonald, A.J., Beitz, A.J., Larson, A.A., Kuriyama, R., Sellitto, C. and Madl, J.E. 1989, Colocalization of glutamate and tubulin in putative excitatory neurons of the hippocampus and amygdala: An immunohistochemical study using monoclonal antibodies, Neuroscience, 30:405–421.CrossRefGoogle Scholar
  28. 28.
    McDonald, J.W. and Johnston, M.V., 1990, Physiological and pathophysiological roles of excitatory amino acids during central nervous system development, Brain Res. Rev. 15: 41–70.CrossRefGoogle Scholar
  29. 29.
    McDonald, J.W., Silverstein, F.S. and Johnston, M.V. 1988, Neurotoxicity of N-methyl-D-aspartate is markedly enhanced in developing rat central nervous system, Brain Res., 459:200–203.CrossRefGoogle Scholar
  30. 30.
    Naik, N.T. 1963, Technical variations in Koelle’s histochemical method for demonstrating cholinesterase activity, Quart. J. Microsc. Sci. 104:89–100.Google Scholar
  31. 31.
    Oja, S.S. and Kontro, P. 1983, Free amino acids in epilepsy: Possible role of taurine, Acta Neurol. Scand., 67(Suppl. 93):5–20.Google Scholar
  32. 32.
    Pearce, I.A., Cambray-Deakin, M.A. and Burgoyne, R.D. 1987, Glutamate acting on NMDA receptors stimulates neurite outgrowth from cerebellar granule cells, FEBS Lett., 223:143–147.CrossRefGoogle Scholar
  33. 33.
    Pokorny, J. and Yamamoto, T. 1981, Postnatal ontogenesis of hippocampal CA1 area in rats. I. Development of dendritic arborisation in pyramidal neurons, Brain Res. Bull., 7:113–120.CrossRefGoogle Scholar
  34. 34.
    Politis, M.J. and Ingoglia, N.A. 1979, Axonal transport of taurine along neonatal and young adult rat optic axons, Brain Res. 166:221–231.CrossRefGoogle Scholar
  35. 35.
    Rashid, N.A. and Cambray-Deakin, M.A. 1992, N-methyl-D-aspartate effects on the growth, morphology, and cytoskeleton of individual neurons in vitro, Dev. Brain Res., 67:301–308.CrossRefGoogle Scholar
  36. 36.
    Rassin, D.K. 1982, Taurine, cysteinesulfinic acid decarboxylase and glutamic acid in brain, Adv. Exp. Med.Biol. 139:257–268.CrossRefGoogle Scholar
  37. 37.
    Roffler-Tarlov, S. and Turey, M. 1982, The content of amino acids in the developing cerebellar cortex and deep cerebellar nuclei of granule cell deficient mutant mice, Brain Res., 247:65–73.CrossRefGoogle Scholar
  38. 38.
    Saransaari, P. and Oja, S.S. 1991, Excitatory amino acids evoke taurine release from cerebral cortex slices from adult and developing mice, Neuroscience, 45:451–459.CrossRefGoogle Scholar
  39. 39.
    Scheff, S.W., Benardo, L.S. and Cotman, C.W. 1980, Decline in reactive fiber growth in the dentate gyrus of aged rats compared to young adult rats following entorhinal cortex removal, Brain Res. 199:21–38.CrossRefGoogle Scholar
  40. 40.
    Schurr, A., Tseng, M.T., West, C.A. and Rigor, B.M. 1987, Taurine improves the recovery of neuronal function following cerebral hypoxia: An in vitro study, Life Sci., 40:2059–2066.CrossRefGoogle Scholar
  41. 41.
    Silverstein, F.S., Chen, R.C. and Johnston, M.V. 1986, The glutamate agonist quisqualic acid is neurotoxic in striatum and hippocampus, Neurosci. Lett., 71:13–18.CrossRefGoogle Scholar
  42. 42.
    Stanfield, B.B. and Cowan, W.M. 1982, The sprouting of septal afferents to the dentate gyrus after lesions of the entorhinal cortex in adult rats, Brain Res., 232:162–170.CrossRefGoogle Scholar
  43. 43.
    Steward, O. 1977, Topographic organization of the projections from the entorhinal area to the hippocam-pal formation of the rat, J. Comp. Neurol. 167:285–314.CrossRefGoogle Scholar
  44. 44.
    Steward, O. and Vinsant, S.L. 1983, The process of reinnervation in the dentate gyrus of the adult rat: A quantitative electron microscopic analysis of terminal proliferation and reactive synaptogenesis, J. Comp. Neurol., 214:370–386.CrossRefGoogle Scholar
  45. 45.
    Sturman, J.A. 1979, Taurine in the developing rabbit visual system: Changes in concentration and axonal transport including a comparison with axonally transported proteins, J. Neurobiol. 10:221–237.CrossRefGoogle Scholar
  46. 46.
    Sturman, J.A. 1993, Taurine in development, Physiol. Rev., 73:119–147.Google Scholar
  47. 47.
    Sturman, J.A., Moretz, R.C., French, J.H. and Wisniewski, H.M. 1985, Postnatal taurine deficiency in the kitten results in a persistence of the cerebellar external granule cell layer: Correction by taurine feeding, J. Neurosci. Res. 13:521–528.CrossRefGoogle Scholar
  48. 48.
    Sturman, J.A., Moretz, R.C., French, J.H. and Wisniewski, H.M. 1985, Taurine deficiency in the developing cat: Persistence of the cerebellar external granule cell layer, J. Neurosci. Res. 13:405–416.CrossRefGoogle Scholar
  49. 49.
    Toth, E., Lathja, A., Sarhan, S. and Seiler, N. 1983, Anticonvulsant effects of some inhibitory neurotransmitter amino acids, Neurochem. Res., 8:291–302.CrossRefGoogle Scholar
  50. 50.
    Trenkner, E. 1990, The role of taurine and glutamate during early postnatal cerebellar development of normal and weaver mutant mice, Adv. Exp. Med. Biol., 268:239–244.Google Scholar
  51. 51.
    Trenkner, E., Gargano, A., Scala, P. and Sturman, J. 1992, Taurine synthesis in cat and mouse in vivo and in vitro, Adv. Exp. Med. Biol., 315:7–14.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Kathy R. Magnusson
    • 1
  1. 1.Department of Anatomy and NeurobiologyColorado State UniversityFort CollinsUSA

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