Taurine is a Substrate of the Anion Exchanger Transport Systems
It is now generally accepted that a number of physiological actions of taurine in the central nervous system (CNS) depend on its intracellular level. The very high resting intracellular taurine concentration in brain mainly results from the functional equilibrium between the rate of its Na+-dependent uptake system and that of its release pathways, since it is known that there is no taurine degradation and the de novo synthesis of the amino acid in this tissue is very poor3. Uptake transport systems of β-amino acids including taurine have been extensively studied and characterized12, and also several genes coding for the responsible proteins have been clonned16. The nature of the pathway allowing the diffusion efflux of taurine from nerve cells, however, is still controversial.
KeywordsNiflumic Acid Krebs Ringer Bicarbonate Taurine Release Taurine Content Taurine Uptake
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