Taurine 2 pp 401-407 | Cite as

Taurine is a Substrate of the Anion Exchanger Transport Systems

  • Rafael Martín del Río
  • Mario Galarreta
  • Nieves Menéndez
  • Conceptión Conejero
  • José M. Solís
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 403)


It is now generally accepted that a number of physiological actions of taurine in the central nervous system (CNS) depend on its intracellular level. The very high resting intracellular taurine concentration in brain mainly results from the functional equilibrium between the rate of its Na+-dependent uptake system and that of its release pathways, since it is known that there is no taurine degradation and the de novo synthesis of the amino acid in this tissue is very poor3. Uptake transport systems of β-amino acids including taurine have been extensively studied and characterized12, and also several genes coding for the responsible proteins have been clonned16. The nature of the pathway allowing the diffusion efflux of taurine from nerve cells, however, is still controversial.


Niflumic Acid Krebs Ringer Bicarbonate Taurine Release Taurine Content Taurine Uptake 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Cabantchik, Z.I. and Greger, R. 1992, Chemical probes for anion transporters of mammalian cell membranes, Am. J.Physiol. 262:C803–C827.Google Scholar
  2. 2.
    Goldstein, L. and Brill, S.R. 1991, Volume-activated taurine efflux from skate erythrocytes: Possible band 3 involvement, Am.J.Physiol.Regul.Integr.Comp.Physiol. 260:R1014–R1020.Google Scholar
  3. 3.
    Huxtable, R.J. 1989, Taurine in the central nervous system and the mammalian actions of taurine, Prog.Neurobiol. 32:471–533.CrossRefGoogle Scholar
  4. 4.
    Joung, J.D., Jones, S.E.M., and Ellory, J.C. 1981, Amino acid transport via the red cell anion transport system, Biochem.Biophys.Acta, 645:157–160.CrossRefGoogle Scholar
  5. 5.
    Kay, M.M.B., Hughes, J., Zagón, I., and Lin, F. 1991, Brain membrane protein band-3 performs the same functions as erythrocyte band-3, Proc.Natl.Acad.Sci. 88:2778–2782.CrossRefGoogle Scholar
  6. 6.
    Kirk, K. and Kirk, J. 1993, Volume-regulatory taurine release from a human lung cancer cell line: Evidence for amino acid transport via a volume-activated chloride channel, FEBS Lett. 336:153–158.CrossRefGoogle Scholar
  7. 7.
    Kopito, R.R., Lee, B.S., Simmons, D.M., Lindesey, A.E., Morgans, C.W., and Schneider, L. 1989, Regulation of intracellular pH by neuronal homolog of the erythrocyte anion exchanger, Cell, 59:927–937.CrossRefGoogle Scholar
  8. 8.
    Kudrycki, K.E., Newman, P.R., and Shull, G.E. 1990, cDNA cloning and tissue distribution of mRNAs for two proteins that are related to the band-3 C1-/HCO3 -exchanger, J.Biol.Chem. 265:462–471.Google Scholar
  9. 9.
    Lambert, I.H. and Hoffmann, E.K. 1994, Cell swelling activates separate taurine and chloride channels in Ehrlich mouse ascites tumor cells, J.Membr.Biol. 142:289–298.Google Scholar
  10. 10.
    Lerma, J., Herranz, A.S., Herreras, O., Abraira, V., and Del Rio, M. 1986, In vivo determination of extracellular concentration of amino acids in the rat hippocampus. A method based on brain dialysis and computerized analysis, Brain Res. 384:145–155.CrossRefGoogle Scholar
  11. 11.
    MacCarthy, K.D. and DeVellis, J. 1980, Preparation of separate astroglial and oligodendroglial cultures from rat cerebral tissue, J.Cell.Biol. 85:890–902.CrossRefGoogle Scholar
  12. 12.
    Oja, S.S. and Kontro, P. 1983, Taurine, in: “Handbook of Neurochemistry, Vol. 3.”, 2nd edition, Lajtha, A. ed., Plenum Press, New York, pp. 501–533.Google Scholar
  13. 13.
    Salhany, J.M. 1990, Erythrocyte Band-3 Protein, CRC Press, Boca Raton, Florida.Google Scholar
  14. 14.
    Sanchez-Olea, R., Morán, J., Schousboe, A., and Pasantes-Morales, H. 1991, Hyposmolarity-activated fluxes of taurine in astrocytes are mediated by diffusion, Neuroscience Letters, 130:233–236.CrossRefGoogle Scholar
  15. 15.
    Solís, J.M., Herranz, A.S., Herreras, O., Lerma, J., and Martín del Río, R. 1988, Low chloride-dependent release of taurine by a furosemide-sensitive process in the in vivo rat hippocampus, Neuroscience, 24:885–891.CrossRefGoogle Scholar
  16. 16.
    Uchida, S., Kwon, H.M., Yamauchi, A., Preston, A.S., Marumo, F., and Handler, J.S. 1992, Molecular cloning of the cDNA for an MDCK cell Na+-and Cl-dependent taurine transporter that is regulated by hypertonicity, Proc.Natl.Acad.Sci.USA, 89:8230–8234.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Rafael Martín del Río
    • 1
  • Mario Galarreta
    • 1
  • Nieves Menéndez
    • 1
  • Conceptión Conejero
    • 1
  • José M. Solís
    • 1
  1. 1.Servicio de Neurobiología Dpto. InvestigatiónHospital Ramón y CajalMadridSpain

Personalised recommendations