Abstract
Sodium- and Cl--dependent taurine transports have been clarified in kidney12 and intestine2. However, there has been only one report, in 1989, for taurine transport at the blood-brain barrier (BBB). This study, using isolated brain capillaries, showed the existence of a Na+-dependent high-affinity uptake system for taurine with a Kt value of about 30 μM at the abluminal membrane4. However, the polarity of taurine transport is difficult to establish with this classical isolated brain capillary technique, because overall uptake may include both luminal and abluminal components.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Audus, K.L. and Borchardt, R.T. 1986, Characteristics of the large neutral amino acid transport system of bovine brain microvessel-endothelial cell monolayers, J.Neurochem. 47:484–488.
Miyamoto, Y., Tiruppathi, C., Ganapathy, V., and Leibach, F.H. 1989, Active transport of taurine in rabbit jejunal brush-border membrane vesicles, Am.J.Physiol. 257:G65–G72.
Tamai, I., Senmaru, M., Terasaki, T., and Tsuji, A. 1995, Na+ and CL--dependent transport of taurine at the blood-brain barrier, Biochem.Pharmacol. 50:1783–1793.
Tayarani, I., Cloëz, I., Lefauconnier, J.-M., and Bourre, J.-M. 1989, Sodium-dependent high-affinity uptake of taurine by isolated rat brain capillaries, Biochim.Biophys.Acta, 985:168–172.
Terasaki, T., Takakuwa, S., Moritani, S., and Tsuji, A. 1991, Transport of monocarboxylic acids at the blood-brain barrier: studies with monolayers of primary cultured bovine brain capillary endothelial cells, J.Pharmacol.Exp.Ther. 258:932–937.
Terasaki, T., Takakuwa, S., Saheki, A., Moritani, S., Shimura, T., Tabata, S., and Tsuji, A. 1992, Absorptive-mediated endocytosis of an adrenocorticotropic hormone (ATCH) analogue, ebiratide, into the blood-brain barrier: studies with monlaters of primary cultured bovine brain capillary endothelial cells, Pharm.Res. 9:529–534.
Törnquist, P. and Alm, A. 1986, Carrier-mediated tranport of amino acids through the blood-retinal and blood-brain barrier, Graefe’s Arch.Clin.Exp.Ophthalmol. 224:21–25.
Tossman, U., Wieloch, T., and Ungerstedt, U. 1985, Gamma-aminobutyric acid and taurine release in the striatum of the rat during hypoglycemic coma, studied by microdialysis, Neuroscience Letters, 62:231–236.
Tsuji, A., Saheki, A., Tamai, I., and Terasaki, T. 1993, Transport mechanism of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors at the blood-brain barrier, J.Pharmacol.Exp. Ther. 261:1085–1090.
Tsuji, A., Tamai, I., Sakata, A., Tenda, Y., and Terasaki, T. 1993, Restricted transport of cyclosporin A across the blood-brain barrier by a multidrug transporter, P-glycoprotein, Biochem.Pharmacol. 46:1096–1099.
Tsuji, A., Terasaki, T., Takabatake, Y., Tenda, T., Tamai, I., Yamashima, T., Moritani, S., Tsuruo, T., and Yamashita, J. 1992, P-Glycoprotein as the durg efflux pump in primary cultured bovine brain capillary endothelial cells, Life Sci. 51:1427–1437.
Zelikovic, I., Stejskal-Lorenz, E., Lohstroh, P., Budreau, A., and Chesney, R.W. 1989, Anion dependence of taurine transport by rat renal brush-border membrane vesicles, Am.J.Physiol. 256:F646–F655.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1996 Springer Science+Business Media New York
About this chapter
Cite this chapter
Tsuji, A., Tamai, I. (1996). Sodium- and Chloride-Dependent Transport of Taurine at the Blood-Brain Barrier. In: Huxtable, R.J., Azuma, J., Kuriyama, K., Nakagawa, M., Baba, A. (eds) Taurine 2. Advances in Experimental Medicine and Biology, vol 403. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0182-8_41
Download citation
DOI: https://doi.org/10.1007/978-1-4899-0182-8_41
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4899-0184-2
Online ISBN: 978-1-4899-0182-8
eBook Packages: Springer Book Archive