Sodium- and Chloride-Dependent Transport of Taurine at the Blood-Brain Barrier
Sodium- and Cl--dependent taurine transports have been clarified in kidney12 and intestine2. However, there has been only one report, in 1989, for taurine transport at the blood-brain barrier (BBB). This study, using isolated brain capillaries, showed the existence of a Na+-dependent high-affinity uptake system for taurine with a Kt value of about 30 μM at the abluminal membrane4. However, the polarity of taurine transport is difficult to establish with this classical isolated brain capillary technique, because overall uptake may include both luminal and abluminal components.
KeywordsBrain Capillary Endothelial Cell Taurine Transport Sodium Gluconate Taurine Uptake Potassium Gluconate
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