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The Effects of Taurine in a Rodent Model of Aging

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Book cover Taurine 2

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 403))

Abstract

A number of excellent review articles have examined the various physiological roles of taurine in adult and developing organisms19, 20, 39. A conclusion that can be drawn from these various reviews is that there is a dearth of information on the role of taurine in aging and senescence. A few studies have examined the tissue content of taurine in aging animal models. In general taurine content seems to decline modestly with advanced age. What is unclear is whether the aging process may increase the demand for the protective and regulatory actions of taurine in cellular homeostasis. This article will briefly review what is known about changes in taurine content and function during senescence and describe our recent studies of taurine supplementation using a common rodent model of aging. We will also discuss the potential consequences of a diminished cytoprotective role of taurine in advanced aging due to a age-related decrement in taurine homeostasis.

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Authors and Affiliations

  1. Department of Pharmacodynamics, College of Pharmacy, University of Florida, JHMHC Box 100487, Gainesville, Florida, 32610, USA

    Ralph Dawson Jr., Baerbel Eppler, Tucker A. Patterson, Debbie Shih & Steve Liu

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  1. Ralph Dawson Jr.
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  2. Baerbel Eppler
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  3. Tucker A. Patterson
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  4. Debbie Shih
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  5. Steve Liu
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Editors and Affiliations

  1. University of Arizona, Tucson, Arizona, USA

    Ryan J. Huxtable

  2. Osaka University Osaka, Osaka, Japan

    Junichi Azuma  & Akemichi Baba  & 

  3. Kyoto Prefectural University of Medicine, Kyoto, Japan

    Kinya Kuriyama  & Masao Nakagawa  & 

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Dawson, R., Eppler, B., Patterson, T.A., Shih, D., Liu, S. (1996). The Effects of Taurine in a Rodent Model of Aging. In: Huxtable, R.J., Azuma, J., Kuriyama, K., Nakagawa, M., Baba, A. (eds) Taurine 2. Advances in Experimental Medicine and Biology, vol 403. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0182-8_4

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  • DOI: https://doi.org/10.1007/978-1-4899-0182-8_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-0184-2

  • Online ISBN: 978-1-4899-0182-8

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