Taurine 2 pp 37-50 | Cite as

The Effects of Taurine in a Rodent Model of Aging

  • Ralph DawsonJr.
  • Baerbel Eppler
  • Tucker A. Patterson
  • Debbie Shih
  • Steve Liu
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 403)


A number of excellent review articles have examined the various physiological roles of taurine in adult and developing organisms19, 20, 39. A conclusion that can be drawn from these various reviews is that there is a dearth of information on the role of taurine in aging and senescence. A few studies have examined the tissue content of taurine in aging animal models. In general taurine content seems to decline modestly with advanced age. What is unclear is whether the aging process may increase the demand for the protective and regulatory actions of taurine in cellular homeostasis. This article will briefly review what is known about changes in taurine content and function during senescence and describe our recent studies of taurine supplementation using a common rodent model of aging. We will also discuss the potential consequences of a diminished cytoprotective role of taurine in advanced aging due to a age-related decrement in taurine homeostasis.


Adult Control Taurine Supplementation Taurine Concentration Taurine Release Taurine Content 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Ralph DawsonJr.
    • 1
  • Baerbel Eppler
    • 1
  • Tucker A. Patterson
    • 1
  • Debbie Shih
    • 1
  • Steve Liu
    • 1
  1. 1.Department of PharmacodynamicsCollege of Pharmacy, University of FloridaGainesvilleUSA

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