Effect of Taurine on Toxicity of the Pyrrolizidine Alkaloid Monocrotaline in Rats
Chapter
Abstract
The pyrrolizidine alkaloid (PA), monocrotaline, is found in a variety of Crotalaria species in the legume family13. It has been responsible for a large number of human intoxications, most dramatically in the Caribbean nations of Jamaica3, 11, 31. For many years, monocrotaline-induced veno-occlusive disease of the liver was endemic, due to the use of the leaves of C. spectabilis in the preparation of the so-called “bush teas” that were commonly consumed. It was not until the 1950s that the cause of the condition was established2 and control measures instituted.
Keywords
Pulmonary Arterial Hypertension Pyrrolizidine Alkaloid Decrease Body Weight Gain Serum Amino Acid Concentration Monocrotaline Injection
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Preview
Unable to display preview. Download preview PDF.
References
- 1.Adams, R. and Rogers, E.F. 1939, The structure of monocrotaline, the alkaloid in Crotalaria spectabilis and Crotalaria retusa, J.Amer. Chem.Soc. 61:2815–2819.CrossRefGoogle Scholar
- 2.Bras, G., Berry, D.M., and Gyorgy, P. 1957, Plants as aetiological factor in veno-occlusive disease of the liver, The Lancet, 960-962.Google Scholar
- 3.Bras, G., Jelliffe, D.B., and Stuart, K.L. 1954, Veno-occlusive disease of liver with nonportal type of cirrhosis, occurring in Jamaica, Archives of Pathology, 57:285–300.Google Scholar
- 4.Chauvin, P., Dillon, J.-C., Moren, A., Talbak, S., and Barakaev, S. 1993, Heliotrope poisoning in Tadjikistan, Lancet, 341:1663.CrossRefGoogle Scholar
- 5.Estep, J.E., Lamé, M.W., Jones, A.D., and Segall, H.J. 1990, N-acetylcysteine-conjugated pyrrole identified in rat urine following administration of two pyrrolizidine alkaloids, monocrotaline and senecionine, Toxicol.Lett. 54:61–69.CrossRefGoogle Scholar
- 6.Fox, D.W., Hart, M.C., Bergeson, P.S., Jarrett, P.B., Stillman, A.E., and Huxtable, R.J. 1978, Pyrrolizidine (Senecio) intoxication mimicking Reye’s syndrome, J.Pediatr. 93:980–982.CrossRefGoogle Scholar
- 7.Gillis, C.N., Huxtable, R.J., and Roth, R.A. 1978, Effect of monocrotaline pretreatment of rats on removal of 5-hydroxytryptamine and norepinephrine by perfused lung, Brit. J.Pharmacol. 63:435–443.CrossRefGoogle Scholar
- 8.Glowaz, S.L., Michnika, M., and Huxtable, R.J. 1992, Detection of a reactive pyrrole in the hepatic metabolism of the pyrrolizidine alkaloid, monocrotaline, Toxicol.Appl.Pharmacol. 115:168–173.CrossRefGoogle Scholar
- 9.Habig, W.H., Pabst, M.J., and Jakoby, W.B. 1974, Glutathione S-transferases: The first enzymatic step in mercapturic acid formation, J.Biol.Chem. 249:7130–7139.Google Scholar
- 10.Horecker, B.L. and Kornberg, A. 1948, The extinction coefficients of the reduced band of pyridine nucleotides, J.Biol.Chem. 175:385–390.Google Scholar
- 11.Huxtable, R.J. 1979, Pyrrolizidine alkaloids and the lung endothelium: a paradigm of lung damage resulting from circulating toxins, in: “Pyrrolizidine (senecio) alkaloids: toxicity, metabolism and poisonous plant control measures”, Cheeke, P.R. ed., Oregon State University, Corvallis, pp. 43-56.Google Scholar
- 12.Huxtable, R.J. 1980, Herbal teas and toxins: novel aspects of pyrrolizidine poisoning in the United States, Perspect.Biol.Med. 24:1–14.Google Scholar
- 13.Huxtable, R.J. 1989, Human health implications of pyrrolizidine alkaloids and herbs containing them, in: “Toxicants of Plant Origin, Vol I: Alkaloids”, Cheeke, P.R. ed., CRC Press, Boca Raton, Florida, pp. 41–86.Google Scholar
- 14.Huxtable, R.J. 1992, Physiological actions of taurine, Physiol.Rev. 72:101–163.Google Scholar
- 15.Huxtable, R.J. 1993, Hepatic nonaltruism and pulmonary toxicity of pyrrolizidine alkaloids, in: “Metabolic Activation and Toxicity of Chemical Agents to Lung Tissue and Cells”, Gram, T.E. ed., Pergamon Press, New York, pp. 215–239.Google Scholar
- 16.Huxtable, R.J. 1996, Taurine: Past, present and future, in: “Taurine: Basic and Clinical Aspects”, Huxtable, R.J., Azuma, J., Nakagawa, M., Kuriyama, K. and Baba, A. eds., Plenum, New York.Google Scholar
- 17.Huxtable, R.J., Ciaramitaro, D., and Eisenstein, D. 1978, The effect of a pyrrolizidine alkaloid, monocrotaline, and a pyrrole, dehydroretronecine, on the biochemical functions of the pulmonary endothelium, Mol.Pharmacol. 14:1189–1203.Google Scholar
- 18.Lafranconi, W.M., Ohkuma, S., and Huxtable, R.J. 1985, Biliary excretion of novel pneumotoxic metabolites of the pyrrolizidine alkaloid, monocrotaline, Toxicon, 23:983–992.CrossRefGoogle Scholar
- 19.Lawrence, R.A., Sunde, R.A., Schwartz, G.L., and Hoekstra, W.G. 1974, Glutathione peroxidase activity in rat lens and other tissues in relation to dietary selenium intake, Exp.Eye Res. 18:563–569.CrossRefGoogle Scholar
- 20.Massey, V. and Williams, C.H. 1965, On the reaction mechanism of yeast glutathione reductase, J.Biol.Chem. 240:4470–4480.Google Scholar
- 21.Mattocks, A.R. 1968, Toxicity of pyrrolizidine alkaloids, Nature (London), 217:723–728.CrossRefGoogle Scholar
- 22.Mattocks, A.R. 1972, Acute hepatotoxicity and pyrrolic metabolites in rats dosed with pyrrolizidine alkaloids, Chem.-Biol.Interact. 5:227–242.CrossRefGoogle Scholar
- 23.Mattocks, A.R., Croswell, S., Jukes, R., and Huxtable, R.J. 1991, Identity of a biliary metabolite formed from monocrotaline in isolated, perfused rat liver, Toxicon, 29:409–415.CrossRefGoogle Scholar
- 24.McGee, J.O., Patrick, R.S., Wood, C.B., and Blumgart, L.H. 1976, A case of veno-occlusive disease of the liver in Britain associated with herbal tea consumption, J.Clin.Path. 29:788–794.CrossRefGoogle Scholar
- 25.Miranda, C.L., Reed, R.L., Guengerich, F.P., and Buhler, D.R. 1991, Role of cytochrome P450IIIA4 in the metabolism of the pyrrolizidine alkaloid senecionine in human liver, Carcinogenesis, 12:515–519.CrossRefGoogle Scholar
- 26.Nigra, L. and Huxtable, R.J. 1992, Hepatic glutathione concentrations and the release of pyrrolic metabolites of the pyrrolizidine alkaloid, monocrotaline, from the isolated perfused liver, Toxicon, 30:1195–1202.CrossRefGoogle Scholar
- 27.Paglia, D.E. and Valentine, W.N. 1967, Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase, J.Lab.Clin.Med. 70:158–169.Google Scholar
- 28.Ridker, P.M., Ohkuma, S., McDermott, W.V., Trey, C., and Huxtable, R.J. 1985, Hepatic veno-occlusive disease associated with the consumption of pyrrolizidine-containing dietary supplements, Gastroenterology, 88:1050–1054.Google Scholar
- 29.Roulet, M., Laurini, R., Rivier, L., and Calame, A. 1988, Hepatic veno-occlusive disease in newborn infant of a woman drinking herbal tea, J.Pediatr. 112:433–436.CrossRefGoogle Scholar
- 30.Stillman, A.E., Huxtable, R., Consroe, P., Kohnen, P., and Smith, S. 1977, Hepatic veno-occlusive disease due to pyrrolizidine poisoning in Arizona, Gastroenterology, 73:349–352.Google Scholar
- 31.Stuart, K.L. and Bras, G. 1957, Veno-occlusive disease of the liver, Quart.J.Med. 26:291–315.Google Scholar
- 32.Tandon, H.D., Tandon, B.N., and Mattocks, A.R. 1978, An epidemic of veno-occlusive disease of the liver in Afghanistan, Am.J.Gastroenterology, 70:607–613.Google Scholar
- 33.Thut, P.D., Hruska, R.E., Huxtable, R.J., and Bressler, R. 1976, Effect of taurine on eating and drinking behavior, in: “Taurine”, Huxtable, RJ. and Barbeau, A. eds., Raven Press, New York, pp. 357–364.Google Scholar
- 34.Williams, D.E., Reed, R.L., Kedzierski, B., Dannan, G.A., Guengerich, F.P., and Buhler, D.R. 1989, Bioactivation and detoxication of the pyrrolizidine alkaloid senecionine by cytochrome P-450 enzymes in rat liver, Drug Metab.Disp. 17:387–392.Google Scholar
- 35.Yan, C.C. and Huxtable, R.J. 1995, Relationship between glutathione concentration and metabolism of the pyrrolizidine alkaloid, monocrotaline, in the isolated, perfused liver, Toxicol.Appl.Pharmacol. 130:132–139.CrossRefGoogle Scholar
- 36.Yan, C.C. and Huxtable, R.J. 1995, Effects of the pyrrolizidine alkaloid, retrorsine, on sulfur metabolism in the liver, Proc. Western Pharmacol.Soc. 38:37–40.Google Scholar
- 37.Yan, C.C. and Huxtable, R.J. 1995, The effect of the pyrrolizidine alkaloids, monocrotaline and trichodesmine, on tissue pyrrole binding and glutathione metabolism in the rat, Toxicon, 33:627–634.CrossRefGoogle Scholar
- 38.Yan, C.C. and Huxtable, R.J. 1995, Effect of the pyrrolizidine alkaloid, monocrotaline, on bile composition of the isolated, perfused rat liver, Life Sci. 57:617–626.CrossRefGoogle Scholar
- 39.Yan, C.C. and Huxtable, R.J. 1996, Effect of pyrrolizidine alkaloids on taurine and sulfur metabolism in the rat liver, in: “Taurine: Basic and Clinical Aspects”, Huxtable, R.J., Azuma, J., Nakagawa, M., Kuriyama, K. and Baba, A. eds., Plenum, New York.Google Scholar
- 40.Yan, C.C. and Huxtable, R.J. 1996, Effects of taurine and guanidinoethane sulfonate on right ventricular hypertrophy induced by the pyrrolizidine alkaloid, monocrotaline, Biochem.Pharmacol. 51:321–329.CrossRefGoogle Scholar
Copyright information
© Springer Science+Business Media New York 1996