Taurine 2 pp 305-314 | Cite as

Inotropic Interventions in the Assessment of Myocardial Failure Associated with Taurine Deficiency in Domestic Cats

  • Mark J. Novotny
  • Patricia M. Hogan
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 403)


Of the amino acids that exist freely in the cytoplasm of myocardial cells, taurine is in highest concentration. While the precise physiological function of taurine in the myocardium has not be defined, taurine may have antioxidant properties8, 9, 29, modulating effects on myocardial calcium23, or a positive inotropic effect3, 32. In hearts isolated from taurine-de-pleted and control rats, Schaffer et al. 29 observed a significantly lower% recovery of mechanical performance in the depleted group than controls following ischemic-reperfusion injury. More recently, we24, 25 and others17 have reported that depletion of myocardial taurine results in cardiac dysfunction characterized by decreased left ventricular (LV) contractility, suggesting that taurine is essential to the maintenance of normal myocardial contractile function. Because taurine is an essential dietary amino acid in the domestic cat, a taurine-deficient state can be achieved in this species through restriction of dietary taurine14. In the cat dietary taurine deficiency leads to a spectrum of changes in myocardial function associated with decreased contractility24, 25. Dilated cardiomyopathy (DCM) appears to be one consequence of taurine deficiency in this species. However, not all cats maintained on taurine-deficient diets develop DCM24, 27, 30.


Dilate Cardiomyopathy Fractional Shorten Contractile Reserve Left Ventricular Systolic Pressure Myocardial Failure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Adams, H.R., Baxter, C.R., and Parker, J.L. 1985, Reduction of intrinsic contractile reserves of the left ventricle by Escherichia coli endotoxin shock in guinea pigs, J.Mol.Cell.Cardiol. 17:575–585.CrossRefGoogle Scholar
  2. 2.
    Apstein, C.S., Mueller, M., and Hood, W.B. 1977, Ventricular contracture and compliance changes with global ischemia and reperfusion, and their effect on coronary resistance in the rat, Circ.Res. 4:206–217.CrossRefGoogle Scholar
  3. 3.
    Azuma, J., Sawamura, A., Awata, N., Ohta, H., Hamaguchi, T., Harada, H., Takihara, K., Hasegawa, H., Yamagami, T., Ishiyama, T., Iwata, H., and Kishimoto, S. 1985, Therapeutic effect of taurine in congestive heart failure: a double-blind crossover trial, Clin.Cardiol. 8:276–282.CrossRefGoogle Scholar
  4. 4.
    Chesney, R. 1988, Taurine: Is it required for infant nutrition? J.Nutr. 118:6–10.Google Scholar
  5. 5.
    Cigarroa, C.G., deFilippi, C.R., Brickner, E., Alvarez, L.G., Wait, M.A., and Grayburn, P.A. 1993, Dobutamine stress echocardiography identifies hibernating myocardium and predicts recovery of left ventricular function after coronary revascularization, Circulation, 88:430–436.CrossRefGoogle Scholar
  6. 6.
    Doring, H.J. and Dehnert, H. 1987, Testing the Langendorff heart for perfect function, in: “The Isolated Perfused Heart According to Langendorff”, Biomesstechnick-Verlag, March, FRG, pp. 60-74.Google Scholar
  7. 7.
    Feigenbaum, H. 1986, Echocardiographic evaluation of cardiac chambers, in: “Echocardiography”, 4th edition, Lea & Febiger, Philadelphia and London, pp. 127–187.Google Scholar
  8. 8.
    Franconi, F., Stendardi, I., Failli, P., Matucci, R., Baccaro, C., Montorsi, L., Bandinelli, R., and Giotti, A. 1985, The protective effects of taurine on hypoxia (performed in the absence of glucose) and on reoxygenation (in the presence of glucose) in guinea-pig heart, Biochem.Pharmacol. 34:2611–2616.CrossRefGoogle Scholar
  9. 9.
    Franconi, F., Stendardi, I., Matucci, R., Bennardini, F., Baccaro, C., and Giotti, A. 1985, A protective effect of taurine on “hypoxic” and “reoxygenated” guinea pig heart, in: “Taurine: biological actions and clinical perspectives”, Oja, S.S., Ahtee, L., Kontro, P. and Paasonen, M.K. eds., Alan R. Liss, New York, pp. 177–182.Google Scholar
  10. 10.
    Gaull, G.E., Pasantes-Morales, H., and Wright, C.E. 1985, Taurine in human nutrition: overview, in: “Taurine: Biological Actions and Clinical Perspectives”, Oja, S.S., Ahtee, L., Kontro, P. and Paasonen, M.K. eds., Alan R. Liss, New York, pp. 3–22.Google Scholar
  11. 11.
    Glantz, S.A. 1987, “Primer of Biostatistics”, McGraw-Hill, New York.Google Scholar
  12. 12.
    Gray, G.E., Landel, A.M., and Meguid, M.M. 1994, Taurine-supplemented total parenteral nutrition and taurine status of malnourished cancer patients, Nutrition, 10:11–15.Google Scholar
  13. 13.
    Haskins, S.C. 1992, Inhalational anesthetics, Vet.Clin.North Am.Small Anim.Pract. 22:297–307.Google Scholar
  14. 14.
    Hayes, K.C. and Trautwein, E.A. 1989, Taurine deficiency syndrome in cats. Vet. Clin. North Am. Small Animal Pract., 19:403–413.Google Scholar
  15. 15.
    Hurwitz, R.A., Siddiqui, A., Caldwell, R.L., Weetman, R.M., and Girod, D.A. 1990, Assessment of ventricular function in infants and children: response to dobutamine infusion, Clin.Nuclear Med. 8:556–559.CrossRefGoogle Scholar
  16. 16.
    Lake, N. 1993, Loss of cardiac myofibrils: Mechanism of contractile deficits induced by taurine deficiency, Am J.Physiol.Heart Circ.Physiol. 264:H1323–H1326.Google Scholar
  17. 17.
    Lake, N., Splawinski, J.B., Juneau, C. and Rouleau, J.L. 1990, Effects of taurine depletion on intrinsic contractility of rat ventricular papillary muscles, Can. J. Physiol. Pharmacol. 68:800–806.CrossRefGoogle Scholar
  18. 18.
    Lawler, D.F., Templeton, A.J., and Monti, K.L. 1993, Evidence for genetic involvement in feline dilated cardiomyopathy, J. Vet. lntern. Med. 7:383–387.CrossRefGoogle Scholar
  19. 19.
    Majerus, T.C., Dasta, J., F., Bauman, J.L., Danziger, L.H., and Ruffuolo, R.R. 1989, Dobutamine: ten years later, Pharmacotherapy, 9:245–259.Google Scholar
  20. 20.
    Malhotra, A. 1990, Regulatory proteins in hamster cardiomyopathy, Circulation Research, 66:1302–1309.CrossRefGoogle Scholar
  21. 21.
    Malhotra, A., Karell, M., and Scheuer, J. 1985, Multiple cardiac contractile protein abnormalities in myopathic Syrian hamsters (BIO 53:58), J.Mol.Cell.Cardiol. 17:95–107.CrossRefGoogle Scholar
  22. 22.
    Malhotra, A. and Scheuer, J. 1990, Troponin-tropomyosin abnormalities in hamster cardiomyopathy, J.Clin.Invest. 86:286–292.CrossRefGoogle Scholar
  23. 23.
    McBroom, M.J. and Welty, J.D. 1985, Effects of taurine and verapamil on heart calcium in hamsters and rats, Comp.Biochem.Physiol. 82C(2):279–281.Google Scholar
  24. 24.
    Novotny, M.J., Hogan, P.M., and Flannigan, G. 1994, Echocardiographic evidence for myocardial failure induced by taurine deficiency in domestic cats, Can.J. Vet.Res. 58:6–12.Google Scholar
  25. 25.
    Novotny, M.J., Hogan, P.M., Paley, D.M., and Adams, H.R. 1991, Systolic and diastolic dysfunction of the left ventricle induced by dietary taurine deficiency in cats, Am.J.Physiol.Heart Circ.Physiol. 261:H121–H127.Google Scholar
  26. 26.
    Pion, P.D., Kittleson, M.D., Lewis, J., Greene, K., Morris, J.G., and Rogers, Q.R. 1991, Taurine deficient myocardial failure: incidence and relation to tissue taurine concentration, J. Vet. lntern. Med. 5:123.Google Scholar
  27. 27.
    Pion, P.D., Kittleson, M.D., Rogers, Q.R., and Morris, J.G. 1987, Myocardial failure in cats associated with low plasma taurine: a reversible cardiomyopathy, Science, 237:764–768.CrossRefGoogle Scholar
  28. 28.
    Previtali, M., Poli, A., Lanzarini, L., Fetiveau, R., Mussini, A., and Ferrario, M. 1993, Dobutamine stress echocardiography for assessment of myocardial viability and ischemia in acute myocardial infarction treated with thrombolysis, Am. J.Cardiol. 72:124G–130G.CrossRefGoogle Scholar
  29. 29.
    Schaffer, S.W., Allo, S., and Mozaffari, M. 1987, Potentiation of myocardial ischemic injury by drug-induced taurine depletion, in: “The Biology of Taurine: Methods and Mechanisms”, Huxtable, R.J., Franconi, F. and Giotti, A. eds., Plenum Press, New York, pp. 151–158.Google Scholar
  30. 30.
    Sisson, D.D., Knight, D.H., Helinski, C., Fox, P.R., Bond, B.R., Harpster, N.K., Moise, N.S., Kaplan, P.M., Bonagura, J.D., Czarnecki, G., and Schaeffer, D.J. 1991, Plasma taurine concentrations and M-mode echocardiographic measures in healthy cats and in cats with dilated cardiomyopathy, J. Vet. lntern. Med. 5:232–238.CrossRefGoogle Scholar
  31. 31.
    Steltzer, H., Simon, P., Owen, A.N., Thalmann, M., and Hammerle, A.F. 1994, The effects of dobutamine therapy in critically ill patients measured by transesophageal echocardiography and intracardiac monitoring, Anaesthesia, 49:432–437.CrossRefGoogle Scholar
  32. 32.
    Takihara, K., Azuma, J., Awata, N., Ohta, H., Hamaguchi, T., Sawamura, A., Tanaka, Y., Kishimoto, S., and Sperelakis, N. 1986, Beneficial effect of taurine in rabbits with chronic congestive heart failure, Am.Heart J. 112:1278–1284.CrossRefGoogle Scholar
  33. 33.
    Tan, L.B. and Littler, W.A. 1990, Measurement of cardiac reserve in cardiogenic shock: implications for prognosis and management, Br.Heart J. 64:121–128.CrossRefGoogle Scholar
  34. 34.
    Vinton, N.E., Laidlaw, S.A., Ament, M.D., and Kopple, J.D. 1986, Taurine concentrations in plasma and blood cells of patients undergoing long-term parenteral nutrition, Am. J. Clin. Nutr., 44:398–404.Google Scholar
  35. 35.
    Vogel, W.M., Lum, D., and Lucchesi, B.R. 1979, Methylprednisolone sodium succinate treatment in global ischemia of the cat isolated heart, J.Cardiovasc.Pharmacol. 1:53–68.CrossRefGoogle Scholar
  36. 36.
    Wyatt, H.L., Haendchen, R.V., Meerbaum, S., and Corday, E. 1983, Assessment of quantitative methods for 2-dimensional echocardiography, Am.J.Cardiol. 52:396–401.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Mark J. Novotny
    • 1
  • Patricia M. Hogan
    • 1
  1. 1.Atlantic Veterinary CollegeUniversity of Prince Edward IslandCharlottetownCanada

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