Effect of Taurine on Angiotensin II-Induced Expression of Immediate Early Response Genes in Primary Cultured Neonatal Rat Heart Cells
Taurine has been used successfully to treat patients with congestive heart failure2. Recently, it has been established that one of the important factors contributing to the development of cardiac hypertrophy and heart failure is angiotensin II3, 9, 14. Angiotensin II is a peptide hormone that plays a major role in the regulation of fluid balance, blood pressure and cardiac function. Its direct cardiac effects include modulation of Na+, H+ and Ca2+ transport, increasing heart rate and mechanical function, stimulation of protein synthesis and enhancing uptake and utilization of glucose3, 9.
KeywordsCardiac Myocytes Cardiac Cell Early Response Gene Beating Rate Taurine Treatment
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