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Taurine 2 pp 297–304Cite as

Effect of Taurine on Angiotensin II-Induced Expression of Immediate Early Response Genes in Primary Cultured Neonatal Rat Heart Cells

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 403))

Abstract

Taurine has been used successfully to treat patients with congestive heart failure2. Recently, it has been established that one of the important factors contributing to the development of cardiac hypertrophy and heart failure is angiotensin II3, 9, 14. Angiotensin II is a peptide hormone that plays a major role in the regulation of fluid balance, blood pressure and cardiac function. Its direct cardiac effects include modulation of Na+, H+ and Ca2+ transport, increasing heart rate and mechanical function, stimulation of protein synthesis and enhancing uptake and utilization of glucose3, 9.

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References

  1. Allo S. N. Carl L.L. and Morgan H.E. 1992, Acceleration of growth of cultured cardiomyocytes and translocation of protein kinase C. Am. J. Physiol. 263:C319–C325.

    CAS  Google Scholar 

  2. Azuma J., Sawamura A., Awata N., Hasegawa H., Ogura K., Harada H., Ohta H., Yamauchi, K., Kishimoto S., Yamagami T., Ueda E. and Ishiyama T. 1983, Double-blind randomized crossover trial of taurine in congestive heart failure. Cum Therap. Res., 34:543–557.

    Google Scholar 

  3. Baker K.M., Booz G.W. and Dostal D.E. 1992, Cardiac actions of angiotensin II: Role of an intracardiac renin-angiotensin system. Ann. Rev. Physiol, 54:227–241.

    Article  CAS  Google Scholar 

  4. Chomczynski P. and Sacchi N. 1987, Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction, Anal. Biochem., 162:156–159.

    Article  CAS  Google Scholar 

  5. Epand R.M. 1990, Relationship of phospholipid hexagonal phases to biological phenomena. Biochem. Cell. Biol., 68:17–23.

    Article  CAS  Google Scholar 

  6. Franconi F., Failli P., Bennardini F., Matucci R., Fazzini A., Stendardi I. and Giotti A. 1989, Taurine modulation of inotropism in guinea pig heart, in: “Taurine and the Heart”, Iwata, H., Lombardini, J.B. and Segawa, T. eds., Kluwer Academic Publishers, Boston, Dordrecht & London, pp. 21–30.

    Chapter  Google Scholar 

  7. Goshima K. and Tonomura Y. 1969, Synchronized beating of embryonic mouse myocardial cells mediated by FL cells in monolayer culture. Exp.Cell.Res. 56:387–392.

    Article  CAS  Google Scholar 

  8. Li Y-P and Lombardini J.B. 1991, Taurine inhibits protein kinase C-catalyzed phosphorylation of specific protein in a rat cortical P2 fraction. J. Neurochem. 56:1747–1753.

    Article  CAS  Google Scholar 

  9. Lindpainter K. and Ganten D. 1991, The cardiac renin-angiotensin system. Circ Res., 68:905–921.

    Article  Google Scholar 

  10. Lombardini J.B. 1992, Effects of taurine on protein phosphorylation in mammalian tissues, in: “Taurine: Nutritional Value and Mechanism of Action”, Lombardini, J.B., Schaffer, S.W. and Azuma, J. eds. Plenum Press, New York, pp. 309–318.

    Google Scholar 

  11. Maturo J. and Kulakowski E.C. 1987, Insulin-like activity of taurine, in: “The Biology of Taurine”, Huxtable, R.J., Franconi F. and Giotti, A. eds., Plenum Press, New York, pp. 217–226.

    Chapter  Google Scholar 

  12. Meinkoth J., and Carmichael G.G. 1984, Hybridization of nucleic acids immobilized on solid supports. Anal. Chem. 138:267–284.

    CAS  Google Scholar 

  13. Polinger I.S. 1970, Separation of cell types in embryonic heart cell cultures. Exp. Cell Res., 63:78–82.

    Article  CAS  Google Scholar 

  14. Sadoshima J. and Izumo S. 1993, Molecular characterization of angiotensin II-induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Circ. Res., 73:413–423.

    Article  CAS  Google Scholar 

  15. Sadoshima J. and Izumo S. 1993, Signal transduction pathways of angiotensin II-induced c-fos gene expression in cardiac myocytes in vitro. Circ. Res., 73:424–438.

    Article  CAS  Google Scholar 

  16. Sadoshima J. and Izumo S. 1993, Mechanical stretch rapidly activates multiple signal transduction pathways in cardiac myocytes: potential involvement of an autocrine/paracrine mechanism. The EMBO J. 12:1681–1692.

    CAS  Google Scholar 

  17. Sadoshima J., Jahn L., Takahashi T., Kulik T.J. and Izumo S. 1992, Molecular characterization of the stretch-induced adaptation of cultured cardiac cells. J. Biol. Chem. 267:10551–10560.

    CAS  Google Scholar 

  18. Schaffer S.W., Azuma J. and Madura J.D. 1995, Mechanisms underlying taurine-mediated alterations in membrane function. Amino Acids 8:231–246.

    Article  CAS  Google Scholar 

  19. Takihara K., Azuma J., Awata N., Ohta H., Hamagachi T., Sawamura A., Tanaka Y., Kishimoto S. and Sperelakis N. 1986, Beneficial effect of taurine in rabbits with chronic congestive heart failure. Am. Heart J. 112:1278–1284.

    Article  CAS  Google Scholar 

  20. Takahashi K., Azuma J., Awata N., Sawamura A., Kishimoto S., Yamagami T., Kishi T., Harada H. and Schaffer S.W. 1988, Protective effect of taurine on the irregular beating pattern of cultured myocardial cells induced by high and low extracellular calcium ion. J. Mol. Cell. Cardiol. 20:397–403.

    Article  CAS  Google Scholar 

  21. Takahashi K., Harada H., Schaffer S.W. and Azuma J. 1992, Effect of taurine on intracellular calcium dynamics of cultured myocardial cells during the calcium paradox, in: “Taurine; Nutritional Value and Mechanisms”, Lombardini, J.B., Schaffer, S.W. and Azuma, J. eds., Plenum Press, New York, pp. 153–161.

    Google Scholar 

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© 1996 Springer Science+Business Media New York

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Takahashi, K., Hashimoto, H., Baba, A., Schaffer, S.W., Azuma, J. (1996). Effect of Taurine on Angiotensin II-Induced Expression of Immediate Early Response Genes in Primary Cultured Neonatal Rat Heart Cells. In: Huxtable, R.J., Azuma, J., Kuriyama, K., Nakagawa, M., Baba, A. (eds) Taurine 2. Advances in Experimental Medicine and Biology, vol 403. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0182-8_31

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  • DOI: https://doi.org/10.1007/978-1-4899-0182-8_31

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-0184-2

  • Online ISBN: 978-1-4899-0182-8

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