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Taurine 2 pp 19-36 | Cite as

Depletion of Feline Taurine Levels by β-Alanine and Dietary Taurine Restriction

  • J. A. Sturman
  • P. Lu
  • J. M. Messing
  • H. Imaki
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 403)

Abstract

It has long been known that cats are dependent on a dietary source of taurine to maintain their body pools because they have a limited capacity for biosynthesis. Taurine deficiency results in retinal degeneration, myocardial failure, decreased immune responsiveness, and a profound adverse effect on feline pregnancy and outcome of the progeny30, 32, 33. Even with zero dietary taurine intake, tissue levels of taurine are only reduced to the point that equilibrium with the biosynthesized taurine is reached, no matter how long cats are maintained on such a diet25, 34. A number of abnormalities have been documented in the brains of surviving kittens from taurine-deprived mothers33, but, to date, no abnormalities have been reported in the brains of taurine-deprived adult cats, other than the decreased concentration of taurine. In this study we have attempted to reduce taurine levels even further by using β-alanine, which competes with taurine for the same transport systems, in the drinking water. β-Alanine was used rather than the more frequently used competitive inhibitor of taurine transport, guanidinoethanesulfonic acid (GES), because cats are able to extensively metabolize GES to form taurine using a transamidinase or amidinohydrolase14, 15, 31. We report the concentrations of taurine and β-alanine in tissues and fluids of cats following 20 weeks of β-alanine ingestion, and document the resulting morphological changes in the cerebellum and profound degenerative changes in the retina.

Keywords

Purkinje Cell Outer Segment Granule Cell Layer Tapetal Cell Outer Nuclear Layer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Campistron, G., Geffard M. and Buijs, R. M. 1986, Immunological approach to the detection of taurine and immunocytochemical results, J. Neurochem. 46:862–868.CrossRefGoogle Scholar
  2. 2.
    Chesney, R.W., Gusowski, N. and Dabbagh, S. 1985, Renal cortex taurine content regulates the adaptive response to altered dietary intake of sulfur amino acids, J. Clin. Invest. 76:2213–2221.CrossRefGoogle Scholar
  3. 3.
    Chesney, R.W., Gusowski, N. and Friedman, A.L. 1983, Renal adaptation to altered dietary sulfur amino acid intake occurs at the luminal brush border membrane, Kidney Int. 24:584–588.CrossRefGoogle Scholar
  4. 4.
    Chesney, R.W., Gusowski, N. and Theissen, M. 1984, Developmental aspects of renal β-amino acid transport. IV. Brush border membrane response to altered intake of sulfur amino acids, Pediatr. Res. 18:611–618.CrossRefGoogle Scholar
  5. 5.
    Chesney, R.W., Lippincott, S., Gusowski, N., Padilla, M. and Zelikovic, I. 1986, Studies on renal adaptation to altered dietary amino acid intake: Tissue taurine responses in nursing and adult rats, J. Nutr. 116:1965–1976.Google Scholar
  6. 6.
    Davies, W.E., Kay, I.S. and Birnso, O.V. 1990, Taurine function in the auditory system, in: “Taurine: Functional Neurochemistry, Physiology, and Cardiology”, Pasantes-Morales, H., Shain, W., Martin, D.L. and Martin del Rio, R. eds., Wiley-Liss, New York, pp. 397–405.Google Scholar
  7. 7.
    Freeman, B. 1978. Myelin sheath thickness and conduction latency groups in the cat optic nerve. J.Comp.Neurol. 181:183–196.CrossRefGoogle Scholar
  8. 8.
    Han, X. and Chesney, R.W. 1994, Expression of taurine transport and its regulation by diet in xenopus laevis oocytes following injection of rat kidney cortex mRNA, in: “Taurine in Health and Disease”, Huxtable, R.J. and Michalk, D. eds., Plenum Press, New York, pp. 121–130.Google Scholar
  9. 9.
    Hayes, K.C., Carey, R.E. and Schmidt, S.Y. 1975, Retinal degeneration associated with taurine deficiency in the cat, Science 188:949–951.CrossRefGoogle Scholar
  10. 10.
    Higgins, J.J., Kaneski, C.R., Bernardini, I., Brady, R.O. and Barton, N.W. 1994, Pyridoxine-responsive hyper-β-alaninemia associated with Cohen’s syndrome, Neurol. 44:1728–1732.CrossRefGoogle Scholar
  11. 11.
    Holopainen, I. 1988, Taurine and β-alanine uptake in primary astrocytes differentiating in culture: Effects of ions, Neurochem. Res. 13:853–858.CrossRefGoogle Scholar
  12. 12.
    Holopainen, I., Malminen, O. and Kontro, P. 1987, Sodium-dependent high-affinity uptake of taurine in cultured cerebellar granule cells and astrocytes, J. Neurosci. Res. 18:479–483.CrossRefGoogle Scholar
  13. 13.
    Hosli, E. and Hosli, L. 1980, Cellular localization of the uptake of [3H]taurine and [3H]β-alanine in cultures of the rat central nervous system, Neurosci. 5:145–152.CrossRefGoogle Scholar
  14. 14.
    Huxtable, R.J. and Lippincott, S.E. 1981, Comparative metabolism and taurine-depleting effects of guanidinoethanesulfonate in cats, mice, and guinea pigs, Arch. Biochem. Biophys. 210:698–709.CrossRefGoogle Scholar
  15. 15.
    Huxtable, R.J., Laird, H.E. and Lippincott, S.E. 1979, The transport of taurine in the heart and the rapid depletion of tissue taurine content by guanidinoethyl sulfonate, J. Pharmacol. Exper. Therapeutics 211:465–471.Google Scholar
  16. 16.
    Imaki, H., Moretz, R.C., Wisniewski, H.M. and Sturman, J.A. 1986, Feline maternal taurine deficiency: Effects on retina and tapetum of the offspring, Devel. Neurosci. 8:160–181.CrossRefGoogle Scholar
  17. 17.
    Lake, N. 1992, Localization of taurine and glial fibrillary acidic protein in human optic nerve using immunocytochemical techniques, in “Taurine: Nutritional Value and Mechanisms of Action”, Lombardini, J.B., Schaffer, S.W. and Azuma, J. eds., Plenum Press, New York, pp. 303–307.Google Scholar
  18. 18.
    Lake, N. and De Marte, L. 1988, Effects of β-alanine treatment on the taurine and DNA content of the rat heart and retina, Neurochem. Res. 13:1003–1006.CrossRefGoogle Scholar
  19. 19.
    Lake, N. and Verdone-Smith, C. 1989, Immunocytochemical localization of taurine in the mammalian retina, Curr. Eye Res. 8:163–173.CrossRefGoogle Scholar
  20. 20.
    Lake, N., Malik, N. and De Marte, L. 1988, Taurine depletion leads to loss of rat optic nerve axons, Vis. Res. 28:1071–1076.CrossRefGoogle Scholar
  21. 21.
    Larsson, O.M., Griffiths, R., Allen, I.C. and Schousboe, A. 1986, Mutual inhibition kinetic analysis of γ-aminobutyric acid, taurine, and β-alanine high-affinity transport into neurons and astrocytes: Evidence for similarity between the taurine and β-alanine carriers in both cell types, J. Neurochem. 47:426–432.CrossRefGoogle Scholar
  22. 22.
    Lowe, J., Morrell, K., Lennox, G., Landon, M. and Mayer, R.J. 1989, Rosenthal fibers are based on the ubiquitination of glial filaments, Neuropathol. Appl. Neurobiol. 15:45–53.CrossRefGoogle Scholar
  23. 23.
    Lu, P., Schuller-Levis, G. and Sturman, J.A. 1991, Distribution of taurine-like immunoreactivity in cerebellum of kittens from taurine-supplemented and taurine-deficient mothers, Int. J. Dev. Neurosci. 9:621–629.CrossRefGoogle Scholar
  24. 24.
    Martin, D.L. and Shain, W. 1979, High affinity transport of taurine and β-alanine and low affinity transport of Ó-aminobutyric acid by a single transport system in cultured glioma cells, J. Biol. Chem. 254:7076–7084.Google Scholar
  25. 25.
    Messing, J.M. and Sturman, J.A. 1993, Evaluation of taurine status in cats consuming diets containing different amounts of taurine by determination of plasma and whole blood taurine concentrations, J. Nutr. Biochem. 4:168–171.CrossRefGoogle Scholar
  26. 26.
    Pasantes-Morales, H., Quesada, O., Carabez, A. and Huxtable, R.J. 1983, Effects of the taurine transport antagonist, guanidinoethane sulfonate, and β-alanine on the morphology of rat retina, J. Neurosci. Res. 9:135–143.CrossRefGoogle Scholar
  27. 27.
    Saransaari, P. and Oja, S.S. 1993, Uptake and release of β-alanine in cerebellar granule cells in primary culture: Regulation of release by glutamatergic and GABAergic receptors, Neurosci. 53:475–481.CrossRefGoogle Scholar
  28. 28.
    Scriver, C.R., Pueschel, S. and Davies, E. 1966, Hyper β-alaninemia associated with β-aminoaciduria and gamma-aminobutyric-aciduria, somnolence and seizures, N. Engl. J. Med. 274:635–643.CrossRefGoogle Scholar
  29. 29.
    Shaffer, J.E. and Kocsis, J. J. 1981, Taurine mobilizing effects of beta alanine and other inhibitors of taurine transport, Life Sci. 28:2727–2736.CrossRefGoogle Scholar
  30. 30.
    Sturman, J.A. 1986, Nutritional taurine and central nervous system development, in “Mental Retardation: Research, Education and Technology Transfer”, Annals New York Academy of Sciences, pp. 196-213.Google Scholar
  31. 31.
    Sturman, J.A., 1990, Taurine deficiency, in: “Taurine: Functional Neurochemistry, Physiology, and Cardiology”, Pasantes-Morales, H., Shain, W., Martin, D.L. and Martin del Rio, R. eds., Wiley-Liss, New York, pp. 385–395.Google Scholar
  32. 32.
    Sturman, J.A., 1992, Review: taurine deficiency and the cat, in “Taurine: Nutritional Value and Mechanisms of Action”, Lombardini, J.B., Schaffer, S.W. and Azuma, J. eds., Plenum Press, New York, pp. 1–5.Google Scholar
  33. 33.
    Sturman, J.A. 1993, Taurine in development, Physiol. Rev. 73:119–147.Google Scholar
  34. 34.
    Sturman, J.A. and Messing, J.M. 1991, Dietary taurine content and feline reproduction and outcome, J. Nutr. 121:1195–1203.Google Scholar
  35. 35.
    Sturman, J.A., Wen, G.Y., Wisniewski, H.M. and Hayes, K.C. 1981, Histochemical localization of zinc in the feline tapetum: Effect of taurine depletion. Histochemistry 72:341–350.CrossRefGoogle Scholar
  36. 36.
    Sturman, J.A., Wen, G.Y., Wisniewski, H.M., Niemann, W.H., and Hayes, K.C., 1982, Taurine and tapetum structure, in “Taurine in Nutrition and Neurology, Vol. 139”, Huxtable, R.J. Pasantes-Morales, H. eds., Plenum Publishing Corporation, New York, pp. 65–78.CrossRefGoogle Scholar
  37. 37.
    Trenkner, E. and Sturman, J.A. 1991, The role of taurine in the survival and function of cerebellar cells in cultures of early postnatal cat, Int. J. Devl. Neurosci. 9:77–88.CrossRefGoogle Scholar
  38. 38.
    Trenkner, E., Gargano, A., Scala, P. and Sturman, J. 1992, Taurine synthesis in cat and mouse in vivo and in vitro, in “Taurine: Nutritional Value and Mechanisms of Action”, Lombardini, J.B., Schaffer, S.W. and Azuma, J. eds., Plenum Press, New York, pp. 7–14.Google Scholar
  39. 39.
    Xu, Y., Lu, P., Imaki, H. and Sturman, J.A. 1993, Feline maternal taurine deficiency: a quantitative morphometric and immunohistochemical study of 8-week-old kitten visual cortex, Biomed. Letts. 48:329–344.Google Scholar

Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • J. A. Sturman
    • 1
  • P. Lu
    • 1
  • J. M. Messing
    • 1
  • H. Imaki
    • 1
  1. 1.Department of Developmental BiochemistryNew York State Institute for Basic Research in Developmental DisabilitiesStaten IslandUSA

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