The Mechanisms of Taurine Mediated Protection against Cell Damage Induced by Hypoxia and Reoxygenation
Recent studies from our laboratory with renal porcine tubular cell cultures gave evidence that taurine in an appropriate dosage and mode of application could markedly reduce the cellular damage due to hypoxia and reoxygenation20, 21. Furthermore, the taurine supplementation led to significantly improved metabolic conditions and stimulated cellular growth processes. Because of the well known pharmacological actions of taurine as modulator of Ca2+ homeostasis6, 10, 12, 13, free radical inhibitor9, 14, osmoregulator6, 16, 17 and the possible role as growth modulating factor, one aim of this study was to elucidate mechanisms which could have been responsible for the protection of the cell cultures during and subsequent to hypoxia. Since many cellular processes have now been recognized to be mediated by changes in cytosolic free Ca2+ and since the free cytosolic free Ca2+ concentration is involved in different cell functions1–3, 5, 8, 11, 15, 18, 19 the influence of taurine on intracellular Ca2+ homeostasis and transmembraneous Ca2+ currents was also investigated.
KeywordsPhorbol Ester Survival Index Cell Volume Regulation Preservation Solution Cellular Volume
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