Taurine 2 pp 213-222 | Cite as

Protective Effect of Taurine on Hypoxia and Reoxygenation-Induced Damage of Human Colon Cells (HT 29)

  • Peter Wingenfeld
  • Dietrich Volker Michalk
  • Angela Sonntag
  • Stefan Paas
  • Thomas Minor
  • Wolf Isselhard
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 403)


Transplantation of the small and large bowel may eventually become a curative treatment for pediatric and adult patients with intestinal failure and short gut syndrome. Since the first description of human allogenic transplantation of intestinal organs such as small and large bowel13, the problem of the suitable preservation of the explanted organ is one of the determining factors for sucessful transplantation. With the recent sucess in transplantation of intestinal organs it has become important to develop better techniques for the preservation of the grafts1, 3, 10, 21. Similar to the proceedings of other allotransplantations, the outcome highly depends on the quality of the preservation of the allograft14, 18, 22, 24, 25, 27, 28. Frequently the long lasting period of cold (hypoxic) storage of the organ and the induced cellular deterioration due to hypoxia limits the possibility of sucessful transplantation. Furthermore the pathophysiological events of the period of reoxygenation subsequent to hypoxia were limiting factors in the transplantation of human organs. Some of these limiting factors are the posthypoxic energy deficiency of an organ2, 26, e. g. a human kidney, the intracellular Ca2+ overload6, osmoregulatory dysfunction induced by deterioration of membrane integrity23, 29, the O2 paradox and membrane oxidation induced by toxic metabolites and free peroxide radicals2, 19.


Survival Index Preservation Solution Viability Rate Taurine Supplementation Human Colon Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Peter Wingenfeld
    • 1
  • Dietrich Volker Michalk
    • 1
  • Angela Sonntag
    • 1
  • Stefan Paas
    • 1
  • Thomas Minor
    • 2
  • Wolf Isselhard
    • 2
  1. 1.Department of PediatricsUniversity of CologneCologneGermany
  2. 2.Institute for Experimental MedicineUniversity of CologneCologneGermany

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