Taurine 2 pp 117-124 | Cite as

Effects of Taurine and Structurally Related Analogues on Ca2+ Uptake and Respiration Rate in Rat Liver Mitochondria

  • M. Palmi
  • F. Fusi
  • G. Youmbi
  • M. Frosini
  • L. Bianchi
  • L. Della Corte
  • G. P. Sgaragli
  • K. F. Tipton
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 403)


Mitochondria from vertebrate sources possess an elaborate system for transporting Ca2+ across their inner membrane. This process includes accumulation of the cation into their matrix, via an uniporter mechanism. This is balanced by electroneutral Ca2+ release mediated by the functioning of a 2 Na+:1 Ca2+ exchanger or “antiporter” in mitochondria from most tissues, including heart, brain and brown adipose tissue, or by a 2H+/Ca2+ antiporter in liver7. In addition to these functions, mitochondria produce about 95% of the common cellular energy as ATP by means of oxidative phosphorylation. Under physiological conditions, Ca2+ transport and energy production seem to be strictly correlated and there is convincing evidence that the intramitochondrial Ca2+ concentration functions as a metabolic control in signalling the mitochondria to modify its metabolic rate in response to increased energy demand. According to the theory of flux control, the steps of Ca2+-mediated metabolic control are distributed and include activation of the Ca2+-sensitive dehydrogenases2, 9 and other Ca2+-sensitive metabolic processes8, 16. In this context, drugs that alter the flux of Ca2+ across mitochondrial membranes could, in theory, play a role in modulating the cellular energetic metabolism.


Brown Adipose Tissue Mitochondrial Oxidative Phosphorylation Proton Leak Couple Respiration Isethionic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • M. Palmi
    • 1
  • F. Fusi
    • 1
  • G. Youmbi
    • 1
  • M. Frosini
    • 1
  • L. Bianchi
    • 2
  • L. Della Corte
    • 2
  • G. P. Sgaragli
    • 1
  • K. F. Tipton
    • 3
  1. 1.Istituto di Scienze FarmacologicheUniversità di SienaSienaItaly
  2. 2.Dipartimento di Farmacologia Preclinica e Clinica “M. Aiazzi-Mancini”Università di FirenzeFirenzeItaly
  3. 3.Department of BiochemistryTrinity CollegeDublin 2Ireland

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