Significance of Taurine Conjugation of Bile Acid in the Biliary Excretion of Bilirubin
Almost all bile acids are conjugated with either taurine or glycine. The conjugates are more potent cholelogues than the unconjugated bile acids. Previously, we have confirmed that administration of taurine increased bile flow and biliary excretion of bile acids in rats with cholestasis induced by α-naphthylisothiocyanate6. Moreover, we found that administration of taurine shortened duration of jaundice in patients with acute hepatitis4. These results suggest a possibility that taurine may accelerate biliary excretion of bilirubin. In the present study, we investigated the effect of taurine on the biliary excretion of bilirubin in normal and mutant hyperbilirubinuric rats4.
KeywordsBile Acid Cholic Acid Biliary Excretion Continuous Intravenous Infusion Sulfur Amino Acid
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