The Role of Peroxisomes in Ether Lipid Synthesis
Peroxisomes belong to a family of subcellular organelles called microbodies that play indispensable roles in cellular metabolism in protozoa, fungi, plant and mammalian cells’. These organelles show a greater variety in enzyme content than other subcellular organelles. Well over 50 enzymes have been reported to be located in microbodies of some kind, but no microbody contains all of them. This is illustrated in table I for a few major microbody processes. Whereas fatty acid [3-oxidation is present in all microbody types, various oxidases producing H202 and catalase are not present in glycosomes, the microbody originally discovered in Trypanosomatidae 2.The glyoxylate cycle is only found in the microbodies of plant seeds and those of yeast and Tetrahymena. Photorespiration and glycolysis are restricted to only one type of microbody, i.e. plant leaf peroxisomes and glycosomes, respectively. Ether lipid synthesis is confined to mammalian peroxisomes3 and, as we recently demonstrated, to trypanosomal glycosomes4, but is not found in plant and yeast microbodies.
KeywordsLipid Synthesis Ether Linkage Ether Lipid Glyoxylate Cycle Subcellular Organelle
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