Platelet-Activating Factor Production in the Stimulated Macrophages is Enhanced by the Cyclooxygenase Inhibitors

  • Masateru Yamada
  • Masako Watanabe
  • Suetsugu Mue
  • Kazuo Ohuchi
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 416)

Abstract

In inflammatory cells, PAF is considered to be synthesized via the remodeling pathway1). Activation of phospholipase A2 releases sn-2 fatty acids, predominantly arachidonic acid, which is metabolized to prostanoids by cyclooxygenase and lipoxygenase. The two different lipid mediators, PAF and prostanoids, are produced from a common precursor in membrane phospholipids when PAF is produced via the remodeling pathway. Because PAF and prostanoids are potent, biologically active mediators, we considered that their production is interdependent.

Keywords

Arachidonic Acid Conditioned Medium PGE2 Production Cyclooxygenase Inhibitor Dibutyryl cAMP 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Masateru Yamada
    • 1
  • Masako Watanabe
    • 1
  • Suetsugu Mue
    • 2
  • Kazuo Ohuchi
    • 1
  1. 1.Department of Pathophysiological Biochemistry Faculty of Pharmaceutical SciencesTohoku UniversitySendai, MiyagiJapan
  2. 2.Department of Health and Welfare Science Faculty of Physical EducationsSendai UniversityFunaoka, MiyagiJapan

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