Lexipafant(BB-882), A Potent PAF Antagonist in Acute Pancreatitis
Acute pancreatitis remains a poorly understood and hence unsatisfactorily treated condition1. In general this is a mild self-limiting disease, which resolves within days and can be managed with non-specific supportive measures and analgesia. In about 25% of cases, however, the disease becomes severe, (defined as pancreatitis associated with organ failure or a local complication such as abscess, pseudocyst or necrosis2). It is this severe group that accounts for much of the morbidity and mortality of the disease. The overall mortality is reported at about 8–10%3, and this occurs almost exclusively in those with severe disease. Published series have shown that organ failure and particularly respiratory failure are the most common complications.
KeywordsAcute Pancreatitis Organ Failure Severe Acute Pancreatitis Experimental Pancreatitis Organ System Failure
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