Phosphatidylinositol-3-Kinase Pathway is Stimulated by Fungal Lipid Containing Cocoa Butter Equivalents (CBE) in FMet-Leu-Phe (FMLP)- and Phorbolester (PMA)-Challenged Human Neutrophils
It is well established that fungi produce fats and oils, although a commercial utilization of these processes with rare exception could not yet be achieved. The reason hereto lied primarily on the high costs of production. Recently, a novel biotechnological process for the production of fungal lipids from Mucor circinelloides by using acetic acid (a cheap carbon source) at sub-toxical levels as the starting substrate has been described (1). The products obtained were oil- and butter-like compounds depending upon the dissolved oxygen tension maintained (Figure 1). The analyses of the lipid demonstrated a γ-linolenic acid (GLA)-rich lipid (so-called fungal oil) and a stearic acid-rich lipid (so-called fungal butter) (2). This first report of low cost production of high value lipids thus raised a caveat for more consideration.
KeywordsCocoa Butter Human Neutrophil Dissolve Oxygen Tension Cocoa Butter Equivalent Mucor Circinelloides
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