Phosphatidylinositol-3-Kinase Pathway is Stimulated by Fungal Lipid Containing Cocoa Butter Equivalents (CBE) in FMet-Leu-Phe (FMLP)- and Phorbolester (PMA)-Challenged Human Neutrophils

  • M. P. Roux
  • J. L. F. Kock
  • S. Nigam
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 416)


It is well established that fungi produce fats and oils, although a commercial utilization of these processes with rare exception could not yet be achieved. The reason hereto lied primarily on the high costs of production. Recently, a novel biotechnological process for the production of fungal lipids from Mucor circinelloides by using acetic acid (a cheap carbon source) at sub-toxical levels as the starting substrate has been described (1). The products obtained were oil- and butter-like compounds depending upon the dissolved oxygen tension maintained (Figure 1). The analyses of the lipid demonstrated a γ-linolenic acid (GLA)-rich lipid (so-called fungal oil) and a stearic acid-rich lipid (so-called fungal butter) (2). This first report of low cost production of high value lipids thus raised a caveat for more consideration.


Cocoa Butter Human Neutrophil Dissolve Oxygen Tension Cocoa Butter Equivalent Mucor Circinelloides 
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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • M. P. Roux
    • 1
  • J. L. F. Kock
    • 2
  • S. Nigam
    • 1
  1. 1.Eicosanoid Research Division Department of GynecologyUniversity Medical Hospital Benjamin FranklinBerlinGermany
  2. 2.Department of Microbiology and BiochemistryUniversity of the Orange Free StateBloemfonteinSouth Africa

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