Endothelin-1 as One of the Mediators of the Interaction between Endothelium and Platelets in Humans

  • Ralf Knöfler
  • Yumiko Takada
  • Akikazu Takada
  • Gerhard Weissbach
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 416)


Endothelin-1 (ET-1) is an endothelium-derived peptide with multiple functions affecting the cardiovascular, renal, neuroendocrine, pulmonary and gastrointestinal system1,2. Elevated plasma levels of ET-1 were found in diseases associated with the activation of platelets, e.g. myocardial infarction, disseminated intravascular coagulation and diabetes. These findings prompted us to investigate the ET-1 effect on platelet aggregation in human whole blood and in platelet rich plasma (PRP).


Platelet Aggregation Platelet Rich Plasma Disseminate Intravascular Coagulation Maximal Aggregation Platelet Poor Plasma 
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  1. 1.
    Yanagisawa, M., Kurihara, H., Kimura, S., Tomobe, Y., Kobayashi, M., Mitsui, Y., Goto, K.. and Masaki, T. (1988) Nature, 332, Botelho, L.H.P.Google Scholar
  2. 2.
    Rubanyi, G.M. and Botelho, L.H.P. (1991) FASEB J., 5, 2713–2720PubMedGoogle Scholar
  3. 3.
    Battistini, B., Filep, J.G., Herman, F. and Sirois, P. (1990) Thromb.Res., 60, 105–108PubMedCrossRefGoogle Scholar
  4. 4.
    Patel, A., Fairbanks, L., Gordge, M.P. and Neild, G. (1989) Thromb.Res., 56, 769–770PubMedCrossRefGoogle Scholar
  5. 5.
    Dockrell, M.E., Haynes, W.G., Williams, B.C. and Webb,D.J. (1993) J.Cardiovasc.Pharmacol., 22 Suppl. 8, S204–5206CrossRefGoogle Scholar
  6. 6.
    Edlund, A. and Wennmalm, A. (1990) Clin.Physiol., 10, 585–590PubMedCrossRefGoogle Scholar
  7. 7.
    Matsumoto, Y., Ozaki, Y., Kariya, T. and Kume, S. (1990) Biochem.Pharmacol., 40, 909–911PubMedCrossRefGoogle Scholar
  8. 8.
    Astarie-Dequeker, C., louzalen, L., David-Dufilho, M. and Devynck, M.A. (1992) Br.J.Pharmacol., 106, 966–971PubMedCrossRefGoogle Scholar
  9. 9.
    Gomez-Garre, D., Guerra, M., Gonzales, E., Lopez-Farre, A., Riesco, A., Caramelo, C., Escamero, J. and Egido, J. (1992) Eur.J.Pharmacol., 224, 167–172PubMedCrossRefGoogle Scholar
  10. 10.
    Joseph, R., Welch, K.M.A., D’Andrea, G. and Riddle, J.R. (1989) Thromb.Res., 53, 485–491PubMedCrossRefGoogle Scholar
  11. 11.
    Ingerman-Wojenski, C.M. and Silver, M.J. (1984) Thromb. Haemostas., 51, 154–156Google Scholar
  12. 12.
    Touyz, R.M. and Schiffrin, E.L. (1995) Clin.Sci.Colch., 88, 277–283PubMedGoogle Scholar
  13. 13.
    Pietraszek, M.H., Takada, Y. and Takada, A. (1992) Eur.J. Pharmacol., 219, 289–293PubMedCrossRefGoogle Scholar
  14. 14.
    Spacey, G.D., Bonser, R.W., Randall, R.W. and Garland, L.G. (1990) Cell.Signal., 2, 329–338PubMedCrossRefGoogle Scholar
  15. 15.
    Hara, 1–1., Osakabe, M., Kitajima, A. Tamao, Y. and Kikumoto, R. (1991) Thromb.Haemostas., 65, 415–420Google Scholar

Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Ralf Knöfler
    • 1
  • Yumiko Takada
    • 2
  • Akikazu Takada
    • 2
  • Gerhard Weissbach
    • 1
  1. 1.Department of PediatricsMedical Faculty of the Technical University DresdenGermany
  2. 2.Department of PhysiologyHamamatsu University School of MedicineJapan

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