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Endothelin-1 as One of the Mediators of the Interaction between Endothelium and Platelets in Humans

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Book cover Platelet-Activating Factor and Related Lipid Mediators 2

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 416))

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Abstract

Endothelin-1 (ET-1) is an endothelium-derived peptide with multiple functions affecting the cardiovascular, renal, neuroendocrine, pulmonary and gastrointestinal system1,2. Elevated plasma levels of ET-1 were found in diseases associated with the activation of platelets, e.g. myocardial infarction, disseminated intravascular coagulation and diabetes. These findings prompted us to investigate the ET-1 effect on platelet aggregation in human whole blood and in platelet rich plasma (PRP).

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References

  1. Yanagisawa, M., Kurihara, H., Kimura, S., Tomobe, Y., Kobayashi, M., Mitsui, Y., Goto, K.. and Masaki, T. (1988) Nature, 332, Botelho, L.H.P.

    Google Scholar 

  2. Rubanyi, G.M. and Botelho, L.H.P. (1991) FASEB J., 5, 2713–2720

    PubMed  CAS  Google Scholar 

  3. Battistini, B., Filep, J.G., Herman, F. and Sirois, P. (1990) Thromb.Res., 60, 105–108

    Article  PubMed  CAS  Google Scholar 

  4. Patel, A., Fairbanks, L., Gordge, M.P. and Neild, G. (1989) Thromb.Res., 56, 769–770

    Article  PubMed  CAS  Google Scholar 

  5. Dockrell, M.E., Haynes, W.G., Williams, B.C. and Webb,D.J. (1993) J.Cardiovasc.Pharmacol., 22 Suppl. 8, S204–5206

    Article  Google Scholar 

  6. Edlund, A. and Wennmalm, A. (1990) Clin.Physiol., 10, 585–590

    Article  PubMed  CAS  Google Scholar 

  7. Matsumoto, Y., Ozaki, Y., Kariya, T. and Kume, S. (1990) Biochem.Pharmacol., 40, 909–911

    Article  PubMed  CAS  Google Scholar 

  8. Astarie-Dequeker, C., louzalen, L., David-Dufilho, M. and Devynck, M.A. (1992) Br.J.Pharmacol., 106, 966–971

    Article  PubMed  CAS  Google Scholar 

  9. Gomez-Garre, D., Guerra, M., Gonzales, E., Lopez-Farre, A., Riesco, A., Caramelo, C., Escamero, J. and Egido, J. (1992) Eur.J.Pharmacol., 224, 167–172

    Article  PubMed  CAS  Google Scholar 

  10. Joseph, R., Welch, K.M.A., D’Andrea, G. and Riddle, J.R. (1989) Thromb.Res., 53, 485–491

    Article  PubMed  CAS  Google Scholar 

  11. Ingerman-Wojenski, C.M. and Silver, M.J. (1984) Thromb. Haemostas., 51, 154–156

    CAS  Google Scholar 

  12. Touyz, R.M. and Schiffrin, E.L. (1995) Clin.Sci.Colch., 88, 277–283

    PubMed  CAS  Google Scholar 

  13. Pietraszek, M.H., Takada, Y. and Takada, A. (1992) Eur.J. Pharmacol., 219, 289–293

    Article  PubMed  CAS  Google Scholar 

  14. Spacey, G.D., Bonser, R.W., Randall, R.W. and Garland, L.G. (1990) Cell.Signal., 2, 329–338

    Article  PubMed  CAS  Google Scholar 

  15. Hara, 1–1., Osakabe, M., Kitajima, A. Tamao, Y. and Kikumoto, R. (1991) Thromb.Haemostas., 65, 415–420

    Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Pediatrics, Medical Faculty of the Technical University Dresden, Germany

    Ralf Knöfler & Gerhard Weissbach

  2. Department of Physiology, Hamamatsu University School of Medicine, Japan

    Yumiko Takada & Akikazu Takada

Authors
  1. Ralf Knöfler
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  2. Yumiko Takada
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  3. Akikazu Takada
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  4. Gerhard Weissbach
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Editor information

Editors and Affiliations

  1. Free University Berlin, Berlin, Germany

    Santosh Nigam  & Gert Kunkel  & 

  2. University of Utah, Salt Lake City, Utah, USA

    Stephen M. Prescott

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© 1996 Springer Science+Business Media New York

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Knöfler, R., Takada, Y., Takada, A., Weissbach, G. (1996). Endothelin-1 as One of the Mediators of the Interaction between Endothelium and Platelets in Humans. In: Nigam, S., Kunkel, G., Prescott, S.M. (eds) Platelet-Activating Factor and Related Lipid Mediators 2. Advances in Experimental Medicine and Biology, vol 416. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0179-8_54

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  • DOI: https://doi.org/10.1007/978-1-4899-0179-8_54

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-0181-1

  • Online ISBN: 978-1-4899-0179-8

  • eBook Packages: Springer Book Archive

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