Abstract
The signal transduction mediating PAF-induced MAPK activation in CHO-cells stably expressing cloned PAF-receptor, has been extensively studied in our group (1). Pertussis toxin (PTX) blocked about 50% of the PAF-induced MAPK activation, without altering phosphatidylinositol (PI) hydrolysis and calcium responses. It was therefore speculated that the PAF-receptor mediates MAPK activation through one PTX-insensitive pathway that yields PI hydrolysis and possibly activation of conventional protein kinase C (cPKC), and another PTX-sensitive pathway that is likely to be independent of calcium and cPKC but mainly remains obscure.
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Ferby, I., Waga, I., Kume, K. and Shimizu, T. Manuscript submitted for publication elsewere
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Ferby, I., Waga, I., Kume, K., Sakanaka, C., Shimizu, T. (1996). PAF-Induced MAPK Activation is Inhibited by Wortmannin in Neutrophils and Macrophages. In: Nigam, S., Kunkel, G., Prescott, S.M. (eds) Platelet-Activating Factor and Related Lipid Mediators 2. Advances in Experimental Medicine and Biology, vol 416. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0179-8_51
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DOI: https://doi.org/10.1007/978-1-4899-0179-8_51
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