Platelet-Activating Factor (PAF): Signalling and Adhesion in Cell-Cell Interactions
PAF is a signalling molecule1 that mediates interactions between cells2. Cell-cell interactions are critical in both physiologic and pathologic processes3,4. Many of the best-characterized effects of PAF involve cellular signalling in the inflammatory and vascular systems, but it also accomplishes signalling functions in the reproductive system, the brain, and in many other organs2. It has the remarkable property of being able to act as an endocrine, paracrine, autocrine, or juxtacrine signal depending on the cell of origin and the specific conditions under which it interacts with target cells5. The amphipathic properties of PAF and its ability to interact with both lipids and proteins contribute to this versatility.
KeywordsHuman Endothelial Cell Adherent Neutrophil Juxtacrine Signalling Opsonized Zymosan Particle Mediate Neutrophil Adhesion
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