Platelet-Activating Factor (PAF): Signalling and Adhesion in Cell-Cell Interactions

  • G. A. Zimmerman
  • M. R. Elstad
  • D. E. Lorant
  • T. M. McIntyre
  • S. M. Prescott
  • Matthew K. Topham
  • A. S. Weyrich
  • Ralph E. Whatley
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 416)


PAF is a signalling molecule1 that mediates interactions between cells2. Cell-cell interactions are critical in both physiologic and pathologic processes3,4. Many of the best-characterized effects of PAF involve cellular signalling in the inflammatory and vascular systems, but it also accomplishes signalling functions in the reproductive system, the brain, and in many other organs2. It has the remarkable property of being able to act as an endocrine, paracrine, autocrine, or juxtacrine signal depending on the cell of origin and the specific conditions under which it interacts with target cells5. The amphipathic properties of PAF and its ability to interact with both lipids and proteins contribute to this versatility.


Human Endothelial Cell Adherent Neutrophil Juxtacrine Signalling Opsonized Zymosan Particle Mediate Neutrophil Adhesion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • G. A. Zimmerman
    • 1
    • 4
  • M. R. Elstad
    • 1
    • 3
    • 4
  • D. E. Lorant
    • 1
    • 6
  • T. M. McIntyre
    • 1
    • 4
    • 5
  • S. M. Prescott
    • 2
    • 3
    • 4
  • Matthew K. Topham
    • 1
    • 4
  • A. S. Weyrich
    • 1
    • 4
  • Ralph E. Whatley
    • 1
    • 4
  1. 1.Nora Eccles Harrison Cardiovascular Research and Training InstituteUSA
  2. 2.Program in Human Molecular Biology and GeneticsUSA
  3. 3.Departments of BiochemistryUniversity of UtahSalt Lake CityUSA
  4. 4.Departments of MedicineUniversity of UtahSalt Lake CityUSA
  5. 5.Departments of PathologyUniversity of UtahSalt Lake CityUSA
  6. 6.Departments of PediatricsUniversity of UtahSalt Lake CityUSA

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