Skip to main content
SpringerLink
Log in

The Role of Platelet-Activating Factor and Its Receptor in Endometrial Receptivity

  • Chapter
Platelet-Activating Factor and Related Lipid Mediators 2

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 416))

Abstract

Successful mammalian pregnancy requires the preparation of a receptive endometrium into which the embryo attaches and invades. Disorders of implantation cause infertility and may be the cause of life-threatening complications in pregnancy1. Impaired implantation is a major cause of peri-implantation embryonic loss2; about 30% of all pregnancies end before they are clinically detected3. Abnormalities might arise in the preparation of the endometrium resulting in failed adhesion or abnormal development of pre or post implanted embryos.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Reginald PW, Beard RW, Chapple J, Forbes PB, Liddel HS, Mowbray JF and Underwood JL (1987) Outcome of pregnancies progressing beyond 28 weeks gestation in women with a history of recurrent miscarriage British Journal of Obstetrics and Gynaecology 94 643–648.

    CAS  Google Scholar 

  2. Yovich JL and Matson PL (1988) Early pregnancy wastage after gamete manipulation British Journal Obstetrics and Gynaecology 95 1120–27.

    Article  CAS  Google Scholar 

  3. Wilcox AJ, Weinberg CR, O’Connor JF, Baird DD, Schlatterer JP, Canfield RE, Armstrong EG and Nisula BC (1988) Incidence of early pregnancy loss New England Journal of Medicine 31 189–194.

    Article  Google Scholar 

  4. Hertig AT (1964) Gestational hyperplasia of endometrium; a morphologic correlation between ova, endometrium, and corpora lutea during early pregnancy Laboratory Investigation 13 1153–1191.

    CAS  Google Scholar 

  5. McRae AC and Heap RB (1988) Uterine vascular permeability, blood flow and extracellular fluid space during implantation in rats Journal of Reproduction and Fertility 82 617–625.

    CAS  Google Scholar 

  6. Kennedy TG and Zamecnik J (1978) The concentration of 6-keto-prostaglandin FI alpha is markedly elevated at the site of blastocyst implantation in the rat Prostaglandins 61 599–605.

    Google Scholar 

  7. Kennedy TG (1983) Embryonic signals and the initiation of blastocyst implantation Australian Journal of Biological Science 36 531–543.

    CAS  Google Scholar 

  8. Kinoshita K, Satoh K, lshihara O, Tsutsumi O, Nakayama M, Kashimura F and Mizuno M (1985) Involvement of prostaglandins in implantation in the pregnant mouse Advances in Prostaglandin, Thromboxane and Leukotriene Research 15 705–607.

    Google Scholar 

  9. Snabes MC and Harper MJK (1984) Site of action of indomethacin on implantation in the rabbit Journal of Reproduction and Fertility 71 559–65.

    Article  CAS  Google Scholar 

  10. Acker G. Hecquet F, Etienne A, Braquet P and Mencia-Huerta JM (1988) Role of platelet-activating factor (PAF) in the ovoimplantation in the rat: effect of the specific PAF-acether antagonist, BN 52021 Prostaglandins 35 233–241.

    CAS  Google Scholar 

  11. O’Neill C (1985) Partial characterisation of the embryo-derived platelet-activating factor in mice Journal of Reproduction and Fertility 75 375–380.

    Google Scholar 

  12. O’Neill C, Gidley-Baird AA, Pike IL and Saunders DM (1987) Use of a bioassay for embryo-derived platelet-activating factor as a means of assessing quality and pregnancy potential of human embryos Fertility and Sterility 47 969–975.

    Google Scholar 

  13. Collier M, O’Neill C, Ammit AJ and Saunders DM (1988) Biochemical and pharmacological characterisation of human embryo-derived platelet-activating factor Human Reproduction 3 993–998.

    CAS  Google Scholar 

  14. Ryan JP, O’Neill C and Wales RG (1990a) Oxidative metabolism of energy substrates by peri-implantation mouse embryos in the presence of platelet-activating factor Journal of Reproduction and Fertility 89 301–307.

    CAS  Google Scholar 

  15. Ryan JP, Spinks NR, O’Neill C, Wales RG (1990b) Implantation potential and fetal viability of mouse embryos cultured in media supplemented with platelet-activating factor Journal of Reproduction and Fertility 89 309–315.

    CAS  Google Scholar 

  16. O’Neill C, Ryan JP, Collier M, Saunders DM, Ammit AJ and Pike IL (1989) Supplementation of in-vitro fertilisation culture media with platelet-activating factor Lancet ii 769–772.

    Google Scholar 

  17. O’Neill C, Ryan JP, Collier M, Saunders DM, Ammit AJ and Pike IL (1992) Outcome of pregnancies resulting from a trial of supplementing human IVF culture media with platelet-activating factor Reproduction, Fertility and Development 4 109–112.

    Article  Google Scholar 

  18. Spinks NR and O’Neill CO (1987) Embryo-derived PAF activity is essential for the establishment of pregnancy in the mouse Lancet i 106–107.

    Google Scholar 

  19. Acker G, Hecquet F, Etienne A, Braquet P, and Mercia-Huerata JM (1988) Role of platelet-activating factor (PAF) in ovoimplantation in the rat: effect of the specific PAF-acether antagonist, BN 52021 Prostaglandins 35 233–241.

    CAS  Google Scholar 

  20. Norris CJ, Peairs WA, Kudolo GB, Newton ER, and Harper MJK (1994) Platelet-activating factor antagonists and implantation in rabbits Journal of Reproduction and Fertility 100 395–401.

    Article  CAS  Google Scholar 

  21. Ahmed A, and Smith SK (1992) Platelet-activating factor stimulates phospholipase C activity in human endometrium Journal of Cellular Physiology 152 207–214.

    CAS  Google Scholar 

  22. Alecozay AA, Harper MJK, Schenken RS and Hanahan DJ (1991) Paracrine interactions between platelet-activating factor and prostaglandins in hormonally-treated human luteal phase endometrium in vitro Journal of Reproduction and Fertility 91 301–312.

    CAS  Google Scholar 

  23. Harper MJK, Kudolo GB, Alecozay AA and Jones MA (1989) Platelet-activating factor (PAF) and blastocyst-endometrial interactions Prog Clin Biol Res 294 305–315.

    CAS  Google Scholar 

  24. Johnston JM, Noriei M, Angle MJ and Hoffman DR (1990) Regulation of the arachidonic acid cascade and PAF metabolism in reproductive tissues. In: Eicosanoids in Reproduction M.D Mitchell ed CRC Press Boston 5–37.

    Google Scholar 

  25. Smith SK and Kelly RW (1988) Effect of platelet-activating factor on the release of PGF2 and PGE, by separated cells of human endometrium. Journal of Reproduction and Fertility 82 271–276.

    Article  PubMed  CAS  Google Scholar 

  26. Ahmed A and Smith SK (1992a) The endometrium: prostaglandins and intracellular signalling at implantation Bailliere’s Clinical Obstetrics and Gynaecology 6 731–754.

    Article  CAS  Google Scholar 

  27. Kudolo GB, Kasamo M and Harper MJK (1991) Autoradiographic localization of platelet-activating factor (PAF) binding sites in the rabbit endometrium during the peri-implantation period Cell Tissue Research 265 231–241.

    CAS  Google Scholar 

  28. Nakamura M, Honda Z, Izumi T, Sakanaka C, Mutoh H, Minami M, Bito H, Seyama Y, Matsumoto T, Noma M and Shimiza T (1991) Molecular cloning and expression of platelet-activating factor receptor from human leukocytes Journal of Biological Chemistry 266 20400–20405.

    CAS  Google Scholar 

  29. Ahmed A, Sage, SO, Plevin R, Shoaibi MA, Sharkey AM and Smith SK (1994) Functional platelet-activating factor receptors linked to inositol lipid hydrolysis, calcium mobilisation and tyrosine kinase activity in the human endometrial HEC-1B cell line Journal of Reproduction and Fertility 101 459–466.

    CAS  Google Scholar 

  30. Berridge MJ and Irvine RF (1989) Inositol phosphates and cell signalling Nature 341 197–205.

    CAS  Google Scholar 

  31. Barzaghi G, Sarau HM and Mong S (1989) Platelet-activating factor-induced phosphoinositide metabolism in differentiated U-937 cells in culture Journal of Pharmacology and Experimental Therapeutics 248 559–566.

    CAS  Google Scholar 

  32. Bonney RC (1985) Measurement of phospholipase A2 activity in human endometrium during the menstrual cycle Journal of Endocrinology 107 183–189.

    CAS  Google Scholar 

  33. Downing I and Poyser NL (1983) Estimation of phospholipase A2 activity in guinea-pig endometrium on day 7 and 16 of the estrous cycle Prostaglandins Leukotrienes in Medicine 12 107–117.

    Article  CAS  Google Scholar 

  34. Exton JH (1990) Signalling through phosphatidylcholine breakdown Journal of Biological Chemistry 265 1–4.

    CAS  Google Scholar 

  35. Ahmed A, Ferriani RA, Plevin R and Smith SK (1992) Platelet-activating factor mediated phosphatidylcholine hydrolysis by phospholipase D in human endometrium Biology of Reproduction 47 59–65.

    CAS  Google Scholar 

  36. Ahmed A, Ferriani RA and Smith SK (1991) Stimulation of phosphatidylinositol 4,5-bisphosphate and phosphatidylcholine by platelet-activating factor (PAF) in human endometrium Journal of Reproduction and Fertility Abstract Series 8: abstract 105.

    Google Scholar 

  37. Cook SJ and Wakelam MJO (1989) Analysis of the water-soluble products of phosphatidylcholine breakdown by ion-exchange chromatography Biochemical Journal 263 581–587.

    CAS  Google Scholar 

  38. Billah MM and Anthes JC (1990) The regulation and cellular functions of phosphatidylcholine hydrolysis Biochemical Journal 269 281–291.

    CAS  Google Scholar 

  39. Morin C, Langlais J and Lambert RD (1992) Possible implication of lysophosphatidylcholine in cell fusion accompanying implantation in the rabbit Satellite Symposium of the Ninth International Congress of Endocrinology (Endocrinology of Embryo-Endometrial Interactions Bordeaux France Abstract 19.

    Google Scholar 

  40. Mobbs CV, Kaplitt M, Kow LM and Pfaff DW. (1991) Mol. Cell. Endocrinol. 80 C187 - C191.

    Article  PubMed  CAS  Google Scholar 

  41. Lippman M, Bolan G and Huff K (1976) Cancer Research 36 4595–4601

    PubMed  CAS  Google Scholar 

  42. Ahmed A, Plevin R, Shoaibi MA, Fountain SA, Ferriani RA and Smith SK (1994) Basic FGF activates phospholipase D in endothelial cells in the absence of inositol lipid hydrolysis. American Journal of Physiology 266 C206 - C212.

    PubMed  CAS  Google Scholar 

  43. Morazova TM, Mitina RL, RauVA and Sidorkina OM (1989) Biokhimiya 54 610–618.

    Google Scholar 

  44. Sidorkina OM, MorazovaTM and Rau VA (1988) Biokhimiya 53 406–411.

    CAS  Google Scholar 

  45. Dhar A and Shukla SD (1991) Involvement of pp60c-src in platelet-activating factor-stimulated platelets. Evidence for translocation from cytosol to membrane Journal of Biological Chemistry 266: 18797–801.

    CAS  Google Scholar 

  46. Ray LB and Sturgill TW (1987) Rapid stimulation by insulin of a serine/threonine kinase in 3T3–L1 adipocytes that phosphorylates microtubule-associated protein in vitro Proceedings of the National Academy of Science USA 84 1502–1506.

    CAS  Google Scholar 

  47. Pulvener BJ, Kymakis JM, Avruch J, Nikolakaki E, and Woodgeti JR (1991) Phosphorylation of c-jun by MAP kinase Nature 353 670–674.

    Google Scholar 

  48. Wood KW, Sarnecki C, Roberts TM and Blenis J (1992) Ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-I and RSK Cell 68 1041–1050.

    CAS  Google Scholar 

  49. Zachary I, Gil J, Lehmann W, Sinnett-Smith J and Rosengurt F (1990) Bombesin, vasopressin and endothelin rapidly stimulate tyrosine phosphorylation in intact Swiss 3T3 cells Proceedings of the National Academy of Science 88 4577–4581.

    Google Scholar 

  50. Saville MK, Paterson A, Malarkey K and Plevin R (1994) Regulation of endothelin-l-and lysophosphatidic acid tyrosine phosphorylation of focal adhesion kinase (pp125FAK) in Rat-1 fibroblasts Biochemical Journal 301 (pt2) 407–14.

    CAS  Google Scholar 

  51. Spinks NR and O’Neill C (1988) Antagonists of embryo-derived platelet-activating factor prevent implantation of mouse embryos Journal of Reproduction and Fertility 84 89–98.

    CAS  Google Scholar 

  52. Bracquet P, Touqui L, Shen Y and Vargaftig BB (1987) Perspectives in platelet-activating research Pharmacological Revue 39 97–145.

    Google Scholar 

  53. Kamata K, Mori T, Shigenobu K and Kasuya Y (1989) Endothelium-dependant vasodilator effects of platelet-activating factor on rat resistance vessels British Journal of Pharmacology 98 1360–1364.

    CAS  Google Scholar 

  54. Juncos LA, Ren Y, Arima S and Ito S (1993) Vasodilator and Constrictor Actions of Platelet-activating Factor in the Isolated Microperfused Afferent Arteriole of the Rabbit Kidney. Role of Endothelium-derived Relaxing Factor/Nitric Oxide and Cyclooxygenase Products Journal of Clinical Investigation 91 1374–1379.

    CAS  Google Scholar 

  55. Morsden PA, Tommy A, Brock TA and Ballerman BJ (1990) Glomerular endothelial cells respond to calcium mobilising agonists with release of EDRF American Journal of Physiology 258 F1295 - F1303.

    Google Scholar 

  56. Filep JG, Foldes-Filep E and Sirois P (1993) Nitric oxide modulates vascular permeability in the rat coronary circulation British Journal of Pharmacology 108 323–326.

    CAS  Google Scholar 

  57. Garg UC and Hassid A (1989) Inhibition of rat mesangial cell mitogenesis by nitric oxide-generating vasodilators American Journal of Physiology 257 (Renal Fluid Electrolyte Physiology 26) F60 - F66.

    CAS  Google Scholar 

  58. Garg UC and Hassid A (1989) Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine mono-phosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells Journal of Clinical Investigation 83 1774–1777.

    CAS  Google Scholar 

  59. Yallampalli C, Izumi H, Byam-Smith M and Garfield RE (1994) An L-arginine-nitric oxide-cyclic guanosine monophosphate system exists in the uterus and inhibits contractility during pregnancy American Journal of Obstetrics and Gynaecology 170 175–185.

    CAS  Google Scholar 

  60. Van Buren GA, Yang DA and Clark KE (1992) Estrogen-induced uterine vasodilatation is antagonised by L-arginine methyl ester, an inhibitor of nitric oxide synthesis American Journal of Obstetrics and Gynaecology 167 828–833.

    Google Scholar 

  61. Kimura T, Yoshida Y and Toda N (1992) Mechanisms of relaxation induced by prostaglandins in isolated canine arteries American Journal of Obstetrics and Gynaecology 167 1409–1416.

    Article  CAS  Google Scholar 

  62. Telfer JF, Lyall F, Norman JE and Cameron IT (1995) Identification of nitric oxide synthase in human uterus Human Reproduction 10 (1) 19–23.

    CAS  Google Scholar 

  63. Giovanelli J, Campos KL and Kaufman S (1991) Proceedings of the National Academy of Science USA 88 7091–7095.

    Article  CAS  Google Scholar 

  64. Bredt DS, Ferris CD and Snyder SH (1992) Nitric Oxide Synthase Regulatory Sites: Phosphorylation by cyclic AMP-dependant Protein Kinase, Protein Kinase C, and Calcium/Calmodulin Protein Kinase; Identification of Flavin and Calmodulin Binding Sites Journal of Biological Science 267 (16) 10976–10981.

    CAS  Google Scholar 

  65. Billah MM and Johnston JM (1983) Identification of phospholipid platelet-activating factor (I-O-alkyl-2acetyl-sn-glycero-3-phosphocholine) in human amniotic fluid and urine Biochemical Biophysical Research Communications 113 51–8.

    CAS  Google Scholar 

  66. Nishihira J, Ishibashi T, Imai Y and Muramatsu T (1984) Mass spectrophotometric evidence for the presence of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) in human amniotic fluid during labour Lipids 19 907–10.

    CAS  Google Scholar 

  67. Bernal AL, Newman GE, Phizackerley PJR, Laird E, Poss C and Barlow DH (1992) Platelet-activating factor levels in human follicular and amniotic fluids European Journal of Obstetrics and Gynaecology and Reproductive Biology 46 39–44.

    CAS  Google Scholar 

  68. Hoffman DR, Romero R and Johnston JM (1990) Detection of platelet-activating factor in amniotic fluid of complicated pregnancies American Journal of Obstetrics and Gynaecology 162 (2) 525–528.

    Article  CAS  Google Scholar 

  69. Billah MM, Di Renzo GC, Ban C, Truong CT, Hoffman DR, Anceschi MM, Bleasdale JE and Johnston JM (1985) Platelet-activating factor metabolism in human amnion and the responses of this tissue to extracellular platelet-activating factor Prostaglandins 30 841–850.

    CAS  Google Scholar 

  70. Bleasdale JE, Bala GA, Thakur NR and McGuire JC (1989) Regulation of prostaglandin production by intrauterine tissue In: Cosmi E, Di Renzo GC (eds) Proceedings of the European Congress of Perinatal Medicine 828–834.

    Google Scholar 

  71. Montrucchio G, Alloatti G, Tetta C, Roffinello C, Emanuelli G and Camussi G (1986) In vitro contractile effect of platelet-activating factor on guinea pig myometrium Prostaglandins 32 539–54.

    CAS  Google Scholar 

  72. Tetta G, Montrucchio G, Alloatti G, et al (1986) Platelet-activating factor contracts human myometrium in vitro Proceedings of the Society for Experimental Biology and Medicine 183 376–81.

    CAS  Google Scholar 

  73. Zhu Y, Word RA and Johnston JM (1992) The presence of platelet-activating factor binding sites in human myometrium and their role in uterine contraction American Journal of Obstetrics and Gynaecology 166 (4) 1222–1227.

    CAS  Google Scholar 

  74. Hwang S, Lee C, Cheah MN and Shen TY (1983) Specific receptor sites for l-O-alky1–2-acetyl-sn-glycero3-phosphocholine (platelet-activating factor) on rabbit platelet and guinea pig smooth muscle membranes Biochemistry 22 4756–63.

    CAS  Google Scholar 

  75. Zhu Y, Hoffman DR, Hwang SB, Miyaura S and Johnston JM (1991) Prolongation of parturition in the pregnant rat following treatment with platelet-activating factor (PAF) receptor antagonists Biology of Reproduction 44 39–42.

    CAS  Google Scholar 

  76. Hoffman DR, Truong CT and Johnston JM (1986) Metabolism and function of platelet-activating factor in rabbit fetal lung development Biochim Biophys 980 (1) 88–96.

    Google Scholar 

  77. Hoffman DR, Truong CT and Johnston JM (1986) The role of platelet-activating factor in human fetal lung maturation and the initiation of parturition American Journal of Obstetrics and Gynaecology 155 (1) 70–75.

    CAS  Google Scholar 

  78. Maki N, Hoffman DR and Johnston JM (1988)-PAF (platelet-activating factor) acetylhydrolase activities in maternal, fetal and newborn rabbit plasma during pregnancy and lactation Proc Natl Acad Sci USA 85 728–732.

    Google Scholar 

  79. Johnston JM and Maki N (1980) PAF and fetal development In: Barnes PJ, Page CP (eds) PAF in Health and Disease Oxford UK; Blackwell Scientific Publications Ltd 297–322.

    Google Scholar 

  80. Johnston MJ and Miyaura S (1990) Platelet-activating factor: the alpha and omega of reproductive biology In: PAF antagonists: now development for clinical application The Woodlands Texas: Portfolio 139–60.

    Google Scholar 

  81. Narahara H, Nishioka Y and Johnston JM (1993) Secretion of Platelet-Activating Factor Acetylhydrolase by Human Decidual Macrophages Journal of Clinical Endocrinology and Metabolism 77 (5) 1258–1262.

    Article  CAS  Google Scholar 

  82. Frenkel RA and Johnston JM (1992) Metabolic conversion of platelet-activating factor into ethanolamine plasmalogen in an amnion-derived cell line Journal of Biological Chemistry 267 19186–91.

    CAS  Google Scholar 

  83. Uemura Y, Lee T and Snyder F (1991) A co-enzyme A-independent transacylase is linked to the formation of platelet-activating factor (PAF) by generating the lyso-PAF intermediate in the remodelling pathway Journal of Biological Chemistry 266 8268–72.

    CAS  Google Scholar 

  84. Nieto ML, Venable ME, Bauldry SA et al (1991) Evidence that hydrolysis of ethanolamine plasmalogens triggers synthesis of platelet-activating factor via a transacylation reaction Journal of Biological Chemistry 266 18699–706.

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Reproductive Physiopathology Group Department of Obstetrics and Gynaecology The Medical School, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK

    Asif Ahmed & Sharon Dearn

Authors
  1. Asif Ahmed
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Sharon Dearn
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Free University Berlin, Berlin, Germany

    Santosh Nigam  & Gert Kunkel  & 

  2. University of Utah, Salt Lake City, Utah, USA

    Stephen M. Prescott

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Springer Science+Business Media New York

About this chapter

Cite this chapter

Ahmed, A., Dearn, S. (1996). The Role of Platelet-Activating Factor and Its Receptor in Endometrial Receptivity. In: Nigam, S., Kunkel, G., Prescott, S.M. (eds) Platelet-Activating Factor and Related Lipid Mediators 2. Advances in Experimental Medicine and Biology, vol 416. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0179-8_45

Download citation

  • DOI: https://doi.org/10.1007/978-1-4899-0179-8_45

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-0181-1

  • Online ISBN: 978-1-4899-0179-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation