PAF Released by Preimplantation Embryos Binds to Albumin

  • A. J. Ammit
  • C. O’Neill
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 416)


The preimplantation embryo from a variety of mammalian species, including humans1, 2, mice3, 4, rabbit5 and sheep6, have been reported to release PAF in vitro. It has been demonstrated that embryo-derived PAF may act as an autocrine stimulant of embryonic metabolism and growth7, 8 and the release of PAF by human embryos created by in vitro fertilization appears to be correlated with embryonic viability and pregnancy potential1, 9, 10. PAF has a range of effects on maternal physiology which include: thrombocytopenia and splenic contraction11; modulation of prostaglandin F2a secretory activity of the uterus in vitro 12 and in vivo 13; changes in the vasculature of the uterine tube of mice14; and the induction of early pregnancy factor expression15.


Preimplantation Embryo Carrier Molecule Electron Impact Mass Spectrometry4 Murine Embryo Royal North Shore Hospital 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • A. J. Ammit
    • 1
  • C. O’Neill
    • 1
  1. 1.Human Reproduction UnitRoyal North Shore Hospital of SydneySt. LeonardsAustralia

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