Epimer-Specific Actions of Hepoxilins A3 and B3 on PAF- and Bradykinin-Evoked Vascular Permeability in the Rat Skin in Vivo

  • Mei Mei Wang
  • Peter M. Demin
  • Cecil R. Pace-Asciak
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 416)

Abstract

The two epimers of hepoxilins A3 (8R and 8S) and B3 (l0R and l0S) were tested for effects on vascular permeability in the rat skin assay, a model for acute inflammation. Results showed epimer-specific effects, the R isomer being active, the S isomer being essentially inactive. While the hepoxilins on their own, at a dose of 20–40 ng/injection intradermally were essentially inactive, they potentiated the actions of bradykinin (both HxA3 and B3 were active) and PAF (only 10R was active) coinjected with the hepoxilins. These results suggest that hepoxilins may mediate (amplify) the actions of inflammatory mediators.

Keywords

Vascular Permeability Platelet Activate Factor Evans Blue Dorsal Skin Research Institute Hospital 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Mei Mei Wang
    • 1
    • 2
  • Peter M. Demin
    • 1
    • 2
  • Cecil R. Pace-Asciak
    • 1
    • 2
  1. 1.Research InstituteHospital for Sick ChildrenTorontoCanada
  2. 2.Department of Pharmacology, Faculty of MedicineUniversity of TorontoTorontoCanada

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