Platelet-Activating Factor

A Possible Role in the Modulation of the Vasomotor Tone and Blood Pressure
  • Rodrigo A. B. Lopes-Martins
  • Claudia V. Araújo
  • Vanessa Estato
  • Sheila Moreira
  • Renato S. B. Cordeiro
  • Eduardo V. Tibiriçá
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 416)


It is well known that the vascular smooth muscle tone is regulated not only by the activity of the sympathetic nervous system, but also by the release of vasoactive factors from the endothelium including nitric oxide (NO), prostacyclin, thromboxane A2 and endothelin (1; 2; 3) that can be induced by both chemical and mechanical stimuli (4). In addition, several studies have reported endothelium-independent vasodilator responses to an unknown endogenous mediator, in rabbit and rat resistance arteries (5;6). PAF is a potent phospholipid mediator released by various cell types including platelets, leukocytes, macrophages, endothelial cells (7) and cultured rat vascular smooth muscle cells (8). This mediator has many biological actions already described (9). Several reports have demonstrated that PAF (<1 μg kg−1, i.v.) induce severe cardiovascular alterations, including a decrease in arterial blood pressure (10; 11), a direct negative chronotropic effect (12; 13) and an increase in vascular permeability (14). The hypotensive effect of PAF has been attributed mainly to the dilation of resistance vessels (15;16), thus suggesting a role for this mediator in the modulation of vascular smooth muscle tone.


Mean Arterial Pressure Systemic Vascular Resistance Carotid Artery Occlusion Carotid Occlusion Vascular Smooth Muscle Tone 
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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Rodrigo A. B. Lopes-Martins
    • 1
  • Claudia V. Araújo
    • 1
  • Vanessa Estato
    • 1
  • Sheila Moreira
    • 1
  • Renato S. B. Cordeiro
    • 1
  • Eduardo V. Tibiriçá
    • 1
  1. 1.Departamento de Fisiologia e FarmacodinâmicaInstituto Oswaldo CruzRio de JaneiroBrasil

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