Effect of SM-12502 on Disseminated Intravascular Coagulation (DIC) in Tumor-Bearing Rats

  • Shigeaki Morooka
  • Yasuhiro Natsume
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 416)


To investigate the role of PAF in tumor-associated disseminated intravascular coagulation (DIC), we have established the tumor-induced DIC model in rats and examined the effect of PAF-antagonist as compared with commonly used anti-DIC drugs. Four days after the intraperitoneal inoculation of rat ascites hepatoma AH-130, DIC-like hematological parameter changes such as decrease in platelet count, prolongation of PTT and increase in FDP were observed. In addition, serum levels of GOT and GPT were increased, indicating that liver injury was provoked. PAF-antagonist SM-12502 inhibited the development of DIC (PT, PTT and FDP) and liver injury. These results indicate that PAF plays an important role in tumor-associated DIC as well as accompanying organ failure.


Tissue Factor Disseminate Intravascular Coagulation Partial Thromboplastin Time Disseminate Intravascular Coagulation Fibrinogen Level 
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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Shigeaki Morooka
    • 1
  • Yasuhiro Natsume
    • 1
  1. 1.Sumitomo Pharmaceuticals Research CenterKonohana, Osaka 554Japan

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