Inhibitors of Arachidonate Metabolism and Effects on PAF Production

  • James D. Winkler
  • Chiu-Mei Sung
  • Lisa A. Marshall
  • Floyd H. Chilton
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 416)


Our understanding of the enzyme Coenzyme A-independent transacylase (CoA-IT) has increased dramatically over the last 10 years. The enzyme catalyses the removal of the fatty acyl group from the sn-2 position of glycerophospholipids (GPL) and transfers it into 1-radyl-2-lyso GPL.1 The enzyme shows striking selectivity for transfer of arachidonate and other long-chain, unsaturated fatty acyl groups. It also shows strong preference for phosphocholine-and phosphoethanolamine-containing GPL, along with a preference for using 1-ether GPL as acceptors for the transferred arachidonate.2 The mechanism of action of CoA-IT has yet to be defined at the molecular level, but CoA-IT is hypothesized to be a member of the family of tranferases typified by lecithin-cholesterol acyl transferase.3 Based on these characteristics, CoA-IT has been presumed to play a role in the movement of arachidonate between GPL that occurs in inflammatory cells.4–7


Human Neutrophil Arachidonate Metabolism Trifluoromethyl Ketone Bowman Gray School Methyl Phenoxy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • James D. Winkler
    • 1
  • Chiu-Mei Sung
    • 1
  • Lisa A. Marshall
    • 1
  • Floyd H. Chilton
    • 2
  1. 1.Division of PharmacologySmithKline Beecham PharmaceuticalsKing of PrussiaUSA
  2. 2.Section on Pulmonary and Critical Care Medicine and Department of BiochemistryBowman Gray School of MedicineWinston-SalemUSA

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