Abstract
Developments in the past decade have highlighted the complexity of signal transduction pathways activated by PAF receptor (PAF-R) (Shukla, 1992; Shimizu et al.,1992). Molecular details and identities of individual components involved in these signalling steps have yet to be resolved. In a broader perspective, PAF receptor activates two major pathways (a) mediated via phospholipases (of types C, D, and A 2) and (b) protein kinases (i.e., PKC, tyrosine kinase, MAP kinase). Further, Ca 2+ mobilization (intracellular release, influx) also play important roles (James-Kracke et al.,1994). How these multiple pathways lead to expression of genes induced by PAF is the topic of this article.
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Shukla, S.D. (1996). Tyrosine Kinase Activation by PAF Leads to Downstream Gene Expression. In: Nigam, S., Kunkel, G., Prescott, S.M. (eds) Platelet-Activating Factor and Related Lipid Mediators 2. Advances in Experimental Medicine and Biology, vol 416. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0179-8_25
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DOI: https://doi.org/10.1007/978-1-4899-0179-8_25
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