Tyrosine Kinase Activation by PAF Leads to Downstream Gene Expression

  • Shivendra D. Shukla
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 416)


Developments in the past decade have highlighted the complexity of signal transduction pathways activated by PAF receptor (PAF-R) (Shukla, 1992; Shimizu et al.,1992). Molecular details and identities of individual components involved in these signalling steps have yet to be resolved. In a broader perspective, PAF receptor activates two major pathways (a) mediated via phospholipases (of types C, D, and A 2) and (b) protein kinases (i.e., PKC, tyrosine kinase, MAP kinase). Further, Ca 2+ mobilization (intracellular release, influx) also play important roles (James-Kracke et al.,1994). How these multiple pathways lead to expression of genes induced by PAF is the topic of this article.


Tyrosine Kinase A431 Cell Platelet Activate Factor Inositol Trisphosphate Downstream Gene Expression 
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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Shivendra D. Shukla
    • 1
  1. 1.Department of Pharmacology School of MedicineUniversity of MissouriColumbiaUSA

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