Stimulation of NF-κB Activation and Gene Expression by Platelet-Activating Factor

  • Richard D. Ye
  • Vladimir V. Kravchenko
  • Zhixing Pan
  • Lili Feng
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 416)


PAF stimulation of NF-κB activation and transcription of immediate-early genes have been investigated in peripheral blood mononuclear cells and in transfected Chinese hamster ovary cells expressing the cloned PAF receptor. These studies identified a G protein-coupled pathway for PAF induction of gene expression and transcription factor activation, which differs from the mechanisms employed by other immediate-early gene inducers. Potential significance of PAF induced NF-κB activation is discussed.


Chinese Hamster Ovary Cell Glomerular Epithelial Cell IKBa Promoter Tissue Factor Gene Expression Autocrine Regulatory Mechanism 
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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Richard D. Ye
    • 1
  • Vladimir V. Kravchenko
    • 1
  • Zhixing Pan
    • 1
  • Lili Feng
    • 1
  1. 1.Department of ImmunologyThe Scripps Research InstituteLa JollaUSA

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