Stimulation of NF-κB Activation and Gene Expression by Platelet-Activating Factor

  • Richard D. Ye
  • Vladimir V. Kravchenko
  • Zhixing Pan
  • Lili Feng
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 416)

Abstract

PAF stimulation of NF-κB activation and transcription of immediate-early genes have been investigated in peripheral blood mononuclear cells and in transfected Chinese hamster ovary cells expressing the cloned PAF receptor. These studies identified a G protein-coupled pathway for PAF induction of gene expression and transcription factor activation, which differs from the mechanisms employed by other immediate-early gene inducers. Potential significance of PAF induced NF-κB activation is discussed.

Keywords

Chinese Hamster Ovary Cell Glomerular Epithelial Cell IKBa Promoter Tissue Factor Gene Expression Autocrine Regulatory Mechanism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Richard D. Ye
    • 1
  • Vladimir V. Kravchenko
    • 1
  • Zhixing Pan
    • 1
  • Lili Feng
    • 1
  1. 1.Department of ImmunologyThe Scripps Research InstituteLa JollaUSA

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