Implication of PAF and Acetylhydrolase (PAF-AH) Activity in Periodontal Disease

  • George Baltas
  • Helen Kotsifaki
  • Smaragdi Antonopoulou
  • Anthoula Kipioti
  • Constantinos A. Demopoulos
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 416)


Platelet-activating factor (PAF) is a bioactive phospholipid produced by activated inflammatory cells such as polymorphonuclear leukocytes, macrophages, platelets and endothelial cells1. Previous research showed that PAF in vivo, increases vascular permeability and infiltration of PMNs 2. Recent studies, however, have implicated PAF with virtually all inflammatory and immune responses 3. So, PAF influences either directly or indirectly many organ and tissue functions. In PMNs PAF induces chemotaxis, aggregation, adherence, lysosomal enzymes release and the production of leukotrienes and free radicals 4 , 5. In monocytes macrophages, low concentrations of PAF cause not only chemotaxis and aggregation but also potentiate, the IL-1, TNF and superoxide production 6,7. Also PAF induces inhibition of lymphocyte proliferation and IL-2 production was observed 8.


Dental Plaque Gingival Crevicular Fluid Rabbit Platelet Adult Periodontitis Lysosomal Enzyme Release 
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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • George Baltas
    • 1
  • Helen Kotsifaki
    • 2
  • Smaragdi Antonopoulou
    • 3
  • Anthoula Kipioti
    • 1
  • Constantinos A. Demopoulos
    • 3
  1. 1.Department of PeriodontologyUniversity of AthensAthensGreece
  2. 2.Department of PhysiologyUniversity of AthensAthensGreece
  3. 3.Department of ChemistryUniversity of AthensAthensGreece

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