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The Prevention of Necrotizing Enterocolitis

The Role of Platelet-Activating Factor Acetylhydrolase

  • Chapter
Platelet-Activating Factor and Related Lipid Mediators 2

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 416))

Abstract

A disease similar, if not identical, to necrotizing enterocolitis (NEC) was first described in the last century in a 2 day-old infant who died of inflammation and perforation of the ileum.1 The incidence of NEC, a disease linked to prematurity, has increased recently due to innovative treatments of premature infants, particularly surfactant replacement. It has been estimated that premature infants suffering from this disease may have a mortality rate as high as 50%. Minimal basic information is known concerning the mechanism(s) involved in the development of NEC. Numerous hypotheses have been invoked as causative or modifying factors of this disease. These include hypothermia, hypoxia, infectious agents, ischemia, various feeding regimes,2 oxygen free radical generation, etc..

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Authors and Affiliations

  1. Departments of Biochemistry, Obstetrics-Gynecology and The Cecil H. and Ida Green Center for Reproductive Biology Sciences, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas, 75235–9051, USA

    Kouei Muguruma, Masayuki Furukawa, Biren Zhao & John M. Johnston

  2. ICOS Corporation, 22021 20th Avenue S.E., Bothell, Washington, 98021, USA

    Larry W. Tjoelker, Greg Dietsch & Patrick W. Gray

Authors
  1. Kouei Muguruma
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  2. Masayuki Furukawa
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  3. Larry W. Tjoelker
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  4. Greg Dietsch
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  5. Patrick W. Gray
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  6. Biren Zhao
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  7. John M. Johnston
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Editors and Affiliations

  1. Free University Berlin, Berlin, Germany

    Santosh Nigam  & Gert Kunkel  & 

  2. University of Utah, Salt Lake City, Utah, USA

    Stephen M. Prescott

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© 1996 Springer Science+Business Media New York

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Muguruma, K. et al. (1996). The Prevention of Necrotizing Enterocolitis. In: Nigam, S., Kunkel, G., Prescott, S.M. (eds) Platelet-Activating Factor and Related Lipid Mediators 2. Advances in Experimental Medicine and Biology, vol 416. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0179-8_22

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  • DOI: https://doi.org/10.1007/978-1-4899-0179-8_22

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-0181-1

  • Online ISBN: 978-1-4899-0179-8

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