Functional and Structural Features of Plasma Platelet-Activating Factor Acetylhydrolase
Platelet-activating factor (PAF) is a potent pro-inflammatory phospholipid that exerts its effects by binding to a receptor on target cells such as monocytes, polymorphonuclear leukocytes, platelets, and smooth muscle cells1. Other phospholipids that have undergone oxidative fragmentation are structurally similar to PAF, bind to its receptor, and mimic its biological properties. Although PAF synthesis is tightly regulated, the fragmented phospholipids arise via unregulated chemical oxidation.
KeywordsCatalytic Triad Active Site Serine Serine Esterase Short Acyl Chain Oxidative Fragmentation
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