Purification and Partial Characterization of the PAF Antagonist from the Saliva of the Leech Hirudo Medicinalis

  • Miriam Orevi
  • Amiram Eldor
  • Maria-Elisabeth Gödeke
  • Meir Rigbi
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 416)


We have found in the saliva of the leech Hirudo medicinalis a low-molecular weight fraction which powerfully inhibits platelet aggregation induced by PAF and thrombin, and by no other aggregating agent (1).


Platelet Aggregation Platelet Rich Plasma Inhibit Platelet Aggregation Leech Therapy Human Platelet Rich Plasma 
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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Miriam Orevi
    • 1
  • Amiram Eldor
    • 2
  • Maria-Elisabeth Gödeke
    • 1
  • Meir Rigbi
    • 1
  1. 1.Department of Biological ChemistryThe Hebrew University of JerusalemJerusalemIsrael
  2. 2.Department of Hematology Tel-Aviv Sourasky Medical Center The Sackler Faculty of MedicineTel-Aviv UniversityIsrael

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