The Enterococcus hirae Copper ATPases

Structure, Function, and Regulation
  • P. Duda
  • D. Strausak
  • M. Solioz


Copper is an essential element by functioning as a cofactor in many redox enzymes such as cytochrome c oxidase, lysyl oxidase, ascorbate oxidase, dopamine β-hydroxylase, tyrosinases and superoxide dismutase. But copper is also very toxic to both eukaryotic and prokaryotic cells: it can initiate the formation of cell damaging radicals which oxidize proteins, DNA and biological membranes. Thus, homeostatic mechanisms have evolved to regulate intracellular copper concentration.


Inverted Repeat Lysyl Oxidase Copper Transport Copper Homeostasis Copper Binding Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • P. Duda
    • 1
  • D. Strausak
    • 1
  • M. Solioz
    • 1
  1. 1.Department of Clinical PharmacologyUniversity of BerneBerneSwitzerland

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