Serum Selenium Levels and Erythrocyte Glutathione Peroxidase Activity in Women with Breast Cancer
The most common type of cancer in women is breast cancer. Its incidence has increasing trend in Slovakia, especially in young women. Animal studies indicated a possible protective effect of selenium on virally or chemically induced mammary tumor (1). Ecological studies showed a negative association between selenium and breast cancer mortality (2,3). Case-control and prospective studies provided inconsistent results about the protective effect of selenium in breast cancer. Several case-control studies showed an inverse association (4–8), while the other studies showed no significant association between blood selenium levels and breast cancer risk (9–13). In addition, no significant association between blood and nail selenium levels and breast cancer risk was reported (11,12,14,15). The present case-control study was undertaken to study serum selenium concentration and erythrocyte glutathione peroxidase activity in women with breast cancer, benign breast disease as well as in women who underwent surgery, and in healthy controls. This case-control study was carried out in cooperation with the National Institute of Oncology in Bratislava.
KeywordsBreast Cancer Breast Cancer Risk GSHPx Activity Selenium Level Benign Breast Disease
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