Selenium Deficiency Triggering Intractable Seizures

A Case Study
  • M. R. Calomme
  • V. Th. Ramaekers
  • W. Makropoulos
  • D. A. Vanden Berghe


Diseases related to selenium deficiency are rare in humans. In some endemic areas of China, selenium deficiency secondary to low soil content contributes to the pathogenesis of Keshan cardiomyopathy (1). In the Western world, selenium deficiency has been reported after prolonged parenteral nutrition (2), and after dietary treatment for phenylketonuria, maple syrup urine disease and propionic acidaemia (3). The selenoenzyme glutathione peroxidase (GSH-Px) act as part of the protective mechanisms (4) against the ubiquitous formation of damaging oxygen radicals and catalyses the reduction of hydrogen peroxide and organic peroxides. Phospholipid hydroperoxide GSH-Px (PHGSH-Px) is membrane associated and reduces different phospholipid-hydroperoxides (4). Since the brain is deficient in catalase (5), the central nervous system can only be protected against hydrogen peroxide and lipid peroxidation by virtue of GSH-Px or PHGSH-Px.


Selenium Concentration Short Bowel Syndrome Selenium Deficiency Selenium Status Maple Syrup Urine Disease 
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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • M. R. Calomme
    • 1
  • V. Th. Ramaekers
    • 2
  • W. Makropoulos
    • 3
  • D. A. Vanden Berghe
    • 1
  1. 1.Department of Pharmaceutical SciencesUniversity of Antwerp (UIA)Belgium
  2. 2.Department of Paediatric NeurologyUniversity of AachenGermany
  3. 3.Department of Occupational HealthUniversity of AachenGermany

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