The Relationship of Dietary Selenium to Carcinogenesis

  • P. D. Whanger

Abstract

Selenium has come full circle in two respects—from toxicity to an essential element and from a carcinogenic agent to an anticarcinogenic element. Until 1957 the only significance of selenium was thought to be its toxicity. Since that time research has been conducted to confirm that it is an essential element, and several seleno-enzymes and selenoproteins are now known (1). In 1943 a paper was published indicating that selenium was a carcinogenic element (2). This created a very damaging image for selenium in that it was thought to be a very toxic element which caused cancer. Even with all the information to indicate otherwise, this image still lingers. For example, in 1975 a IARC review on selenium and selenium-containing compounds concluded that “the available data provide no suggestion that selenium is carcinogenic to man” (3). Nevertheless, even today a number of selenium compounds are marketed with a warning label that indicates the substance may be a carcinogen. There are numerous reviews on the relationship of selenium to cancer and a few of them are listed here (1, 4–6).

Keywords

Selenium Compound Warning Label Carcinogenic Agent Roswell Park Cancer Institute Selenoamino Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    J.A. Milner, CRC Press, Boca Raton, Chap. 8 (1995).Google Scholar
  2. 2.
    A.A. Nelson, O. G. Fitzhugh and H. O. Calvery, Cancer Res. 3, 230 (1943)Google Scholar
  3. 3.
    International Agency for Research on Cancer (IARC) 9, 245 (1993).Google Scholar
  4. 4.
    C. Ip, and H. E. Ganther, in Cancer Chemoprevention, L. Wattenberg, et al., eds, CRC press, Boca Raton, pp. 479–488(1992).Google Scholar
  5. 5.
    G.F. Combs, and S. B. Combs. Academic press, New York, Chap. 10 (1986).Google Scholar
  6. 6.
    P.D. Whanger, J. Trace Elem. Elect. Health Dis. 6, 209 (1992).Google Scholar
  7. 7.
    R.J. Schamberger, and C. E. Willis, CRC Crit. Rev. Lab. Sci. 2, 211 (1971).CrossRefGoogle Scholar
  8. 8.
    G.N. Schrauzer, D. A. White and C. J. Schneider, Bioinorgan. Chem. 7, 23 (1977).CrossRefGoogle Scholar
  9. 9.
    P.D. Whanger, J. A. Schmitz and J. H. Exon. Nutr. Cancer 3, 240 (1982).CrossRefGoogle Scholar
  10. 10.
    C. Ip, J. Natl Cancer Inst. 80, 258 (1988).CrossRefGoogle Scholar
  11. 11.
    C. Ip, and H. E. Ganther, Carcinogenesis 9, 1481 (1988).CrossRefGoogle Scholar
  12. 12.
    C. Ip, Cancer Res. 41,4386 (1981).Google Scholar
  13. 13.
    C. Ip, C. Hayes, R. M. Budnik and H. E. Ganther, Cancer Res. 51, 595 (1991).Google Scholar
  14. 14.
    C. Ip et al., Carcinogenesis 15, 187 (1994).CrossRefGoogle Scholar
  15. 15.
    C. Ip, H. Thompson and H. E. Ganther, Carcinogenesesis, 15, 2879 (1994).CrossRefGoogle Scholar
  16. 16.
    C. Ip, and D. J. Lisk, Carcinogenesis 15, 573 (1994).CrossRefGoogle Scholar
  17. 17.
    C. Ip, D. J. Lisk and G. S. Stoewsand, Nutr. Cancer 17, 279 (1992).CrossRefGoogle Scholar
  18. 18.
    C. Ip and D. J. Lisk, Carcinogenesis 15, 1881 (1994).CrossRefGoogle Scholar
  19. 19.
    P.D. Whanger, and J. A. Butler, J. Nutr. 118, 846 (1988).Google Scholar
  20. 20.
    M.A. Beilstein and P. D. Whanger, J. Nutr. 116, 1701 (1986).Google Scholar
  21. 21.
    X.J. Cai, et al., J. Agric. Food Chem. 43, 1754 (1995).CrossRefGoogle Scholar
  22. 22.
    J.Y. Li et al., J. Natl. Cancer Institute 85, 1483 (1995).Google Scholar

Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • P. D. Whanger
    • 1
  1. 1.Oregon State UniversityCorvallisUSA

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