Antibacterial Properties of Some Metal Salts and Lansoprazole against Helicobacter pylori Using MIC Determination, Electron Microscopy and Flow Cytometry Analysis
Helicobacter pylori associated gastritis responds to a variety of triple therapies. The combination of a proton pump inhibitor, amoxicillin and clarithromycin is particulary effective (1,2,3) and is one of the triple therapies recommended by the French conference of consensus. Amoxicillin and bismuth are among the most useful of the antimicrobial drugs that do not induce resistance in H. pylori. Currently, the triple therapy of asymptomatic gastritis does not seem to be suitable because of the cost and the risk of developping antibacterial resistance. However, a potential therapy using different metal salts could be envisaged for patients who do not have peptic ulcer. In fact, metals such as bismuth, silver or aluminium have been used in the treatment of gastritis for their topical activity but some of them have also bacteriostatic properties (4).
KeywordsMetal Salt Flow Cytometry Analysis Silver Nitrate Triple Therapy Aluminium Hydroxide
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