Abstract
The Superoxide anion radical, O2 −, plays a key role in the initiation stage of oxidative damage in biological systems (1). The main line of defense in mammalian organisms for controlling intracellular, and to a lesser extent extracellular, O2 − radicals are the Cu/Zn and Mn-containing Superoxide dismutase (SOD) enzymes and, recently, the application of SOD as a drug has attracted much attention (2). Since various problems are associated with using an enzyme as a drug (cost, bioavailability, stability, immunogenicity), non-toxic and low-mass metal complexes that catalyze the dismutation of O2 − might be able to substitute for SOD in such applications.
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Souchard, J.P., Fabre, P.L., Patau, J.P., Massol, M., Castan, P., Nepveu, F. (1996). Manganese(II) Complexes with Orotic Acid Derivatives as Scavengers of Superoxide Radicals. In: Nève, J., Chappuis, P., Lamand, M. (eds) Therapeutic Uses of Trace Elements. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0167-5_43
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DOI: https://doi.org/10.1007/978-1-4899-0167-5_43
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