The Influence of Lithium and Magnesium on Digestive Lesions Induced by Platelet Activating Factor in Rats

  • M. Nechifor
  • B. I. Neughebauer
  • M. Adomnicai
  • E. Teslariu
  • C. Filip


The Platelet Activating Factor (PAF) is a lipidic autacoid having the structure 1-O-alkyl-2-acetyl-sn-glyceryl-3′-phosphorylcholine and is widely spread in a great variety of human and animal tissues (1–3). Numerous physiological and pathological involvements of PAF are known. Several authors (1,4–6) have shown that PAF produces ulceration and hemorrhages in the digestive tract. The ulcerogenic effect of PAF was observed after intravenous or topical administration at the gastric mucosa level. The mechanisms through which PAF exerts its lesional activity at the level of gastric mucosa are very complex and not completely identified. Among mechanisms proposed to explain the ulcerogenic effects of PAF are: damages of microcirculation of gastric mucosa (7), increase of free radical production (8), increase of acid secretion, formation of platelets microaggregates, increase of aggregation of neutrophils and release of lysosomal enzymes (9). In this paper, the effects of magnesium, calcium and lithium on the lesions produced by intravenous administration of PAF in rats were investigated.


Gastric Mucosa Platelet Activate Factor Gastric Lesion Lesional Score Gastric Mucosa Lesion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    P. Braquet, L. Touqui, T.S. Shen, B.B. Vargaftig, Pharmacological Rev. 39, 97–145 (1987).Google Scholar
  2. 2.
    G.E. Plante, R.L. Hebert, in Ginkgolides — Chemistry, Biology, Pharmacology and Clinical Perspectives, P. Braquet, ed., J.R. Prous Science, Barcelona, pp. 5775–602 (1988).Google Scholar
  3. 3.
    J. Benveniste, P.M. Hemson, CG. Cochrane, J. Exp Med. 136, 1356–1377 (1972).CrossRefGoogle Scholar
  4. 4.
    B.J.R. Whittle, T. Morishita, Y. Ohya, F.W. Leung, P.H. Guth, Am. J. Physiol. 251, G772–778 (1986).Google Scholar
  5. 5.
    J.L. Wallace, Whittle B.J.R., Prostaglandins 31, 989–998 (1986).Google Scholar
  6. 6.
    A.C. Rosam, J.L. Wallace, B.J.R. Whittle, Nature 319, 54–56 (1986).CrossRefGoogle Scholar
  7. 7.
    J. Bjork, L. Lindbone, B. Gerdin, G. Smedegard, K.E. Arfors, J. Benveniste, Acta Phisiol. Scand. 119, 305–308(1983).CrossRefGoogle Scholar
  8. 8.
    T. Binnaka, T. Yamaguchi, J. Hirohara, Scand. J. Gastroenterol 66, 2629–2634 (1989).Google Scholar
  9. 9.
    J.W. Doebber, M.S. Wu, T.Y. Shan, Biochem. Biophys. Res. Commun. 125, 980–987 (1984).CrossRefGoogle Scholar
  10. 10.
    A. Etienne, N. Baraggi, in Ginkgolides—Chemistry, Biology, Pharmacology and Clinical Perspectives, P. Braquet, ed., J.R. Prous Science, Barcelona, pp. 115–125 (1988).Google Scholar
  11. 11.
    P.J. Wade, Thromb. Res. 41, 251–262 (1986).CrossRefGoogle Scholar
  12. 12.
    S. Nigam, S. Muller, C. Benedetto, J. Lipid. Mediat. 12, 323–328 (1989).Google Scholar
  13. 13.
    M. Koltai, D. Hosford, Ph. Guinot, A. Esanu, P. Braquet, Drug 42, 174–200 (1991).CrossRefGoogle Scholar
  14. 14.
    P.V. Peplow, D.D. Mikhailidis, Prostagland. Leuk. Essent. Fatty Acids 41, 71–82 (1990).CrossRefGoogle Scholar
  15. 15.
    A. Dembinska-Kiec, B.A. Peskar, M.K. Muller, B.M. Peskar, Prostaglandins 37, 69–91 (1989).Google Scholar
  16. 16.
    S.H. McColl, E. Krump, P.P. McDonad, M. Braquet, P.H. Naccache, J. Lipid. Mediators 2, S119–S128 (1990).Google Scholar
  17. 17.
    M. Nechifor, B.I. Neughebauer, M. Adomnicai, E. Teslaru, C. Filip, A. Negru, Rom. J. Physiol. 30, 151–154 (1993).Google Scholar

Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • M. Nechifor
    • 1
  • B. I. Neughebauer
    • 1
  • M. Adomnicai
    • 1
  • E. Teslariu
    • 1
  • C. Filip
    • 1
  1. 1.Department of PharmacologyUniversity of Medicine and PharmacyIasiRomania

Personalised recommendations