Metabolism of Selenium in a Model of Mesenteric Ischemia-Reperfusion Injury

Role of N-Acetylcysteine
  • Ph. Bauer
  • F. Belleville-Nabet
  • E. Vauthier
  • C. Colin
  • F. Dubois
  • J. C. Guédenet
  • O. Bodenreider
  • B. Dousset
  • P. Nabet
  • J. P. Mallié
  • A. Larcan

Abstract

Selenium is the essential co-factor of glutathione peroxidase involved in free radicals detoxification. In case of ischemia-reperfusion and depending on the model studied, the tissue variations of selenium and reduced glutathione can be related to various mecanisms (1); among others, a redistribution has been suggested. The aim of this study was to confirm this phenomena and to study the effect of N-acetylcysteine (NAC), a free radical scavenger (2), in a model of moderate intestinal ischemia-reperfusion injury by using hemodynamic, biochemical and histological data.

Keywords

Glutathione Peroxidase Superior Mesenteric Artery GSHPx Activity Fulminant Hepatic Failure Apical Portion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Ph. Bauer
    • 1
  • F. Belleville-Nabet
    • 2
  • E. Vauthier
    • 3
  • C. Colin
    • 3
  • F. Dubois
    • 2
  • J. C. Guédenet
    • 4
  • O. Bodenreider
    • 5
  • B. Dousset
    • 2
  • P. Nabet
    • 2
  • J. P. Mallié
    • 3
  • A. Larcan
    • 1
  1. 1.Service de Réanimation MédicaleHôpital CentralNancy CedexFrance
  2. 2.Laboratoire de BiochimieHôpital CentralNancy CedexFrance
  3. 3.Laboratoire de NéphrologieFaculté de MédecineVandoeuvreFrance
  4. 4.Laboratoire d’Anatomo-PathologieFaculté de MédecineVandoeuvreFrance
  5. 5.Département D’information MédicaleHôpital CentralNancy CedexFrance

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