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Therapeutic Uses of Trace Elements pp 229–232Cite as

Metabolism of Selenium in a Model of Mesenteric Ischemia-Reperfusion Injury

Role of N-Acetylcysteine

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Abstract

Selenium is the essential co-factor of glutathione peroxidase involved in free radicals detoxification. In case of ischemia-reperfusion and depending on the model studied, the tissue variations of selenium and reduced glutathione can be related to various mecanisms (1); among others, a redistribution has been suggested. The aim of this study was to confirm this phenomena and to study the effect of N-acetylcysteine (NAC), a free radical scavenger (2), in a model of moderate intestinal ischemia-reperfusion injury by using hemodynamic, biochemical and histological data.

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References

  1. D.D. Gibson, DJ. Brackett, R.A. Squires, A.K. Balla, M.R. Lerner, P.B. McCay, L.R. Pennington, Free Radie. Biol. Med. 14, 427–433 (1993).

    Article  CAS  Google Scholar 

  2. K.R. Knight, K. MacPhadyen, D.A. Lepore, N. Kuwata, P.A. Eadie, B. McO’brien, Clin.Sci. 81, 31–6 (1991).

    CAS  Google Scholar 

  3. Ph. Bauer, F. Belleville-Nabet, F. Watelet, F. Dubois, A. Larcan, Biol. Trace Elem.Res. 47, 157–163 (1995).

    Article  CAS  Google Scholar 

  4. F. Raul, M. Galluser, R. Schleiffer, F. Gossé, M. Hasselmann, N. Seiler, Digestion 56, 400–405 (1995).

    Article  CAS  Google Scholar 

  5. H.J. Schiller, P.M. Reilly, G.B. Bulkley, Crit. Care Med. 21, S92–S102 (1993).

    Article  CAS  Google Scholar 

  6. P.M. Harrison, J.A. Wendon, A.E.S. Gimson, GJ.M. Alexander, R. Williams, N. Engl. J. Med. 324, 1852–1857(1991).

    Article  CAS  Google Scholar 

  7. CD. Spies, K. Reinhart, I. Witt, A. Meier-Hellmann, L. Hannemann, D.L. Bredle, W. Schaffartzik, Crit. Care Med. 22, 1738–1746(1994).

    CAS  Google Scholar 

  8. O.I. Aruoma, B. Halliwell, B.M. Hoey, J. Butler, J. Free Radicals Biol. Med. 6, 593–597 (1989).

    Article  CAS  Google Scholar 

  9. H. Zhang, H. Spapen, D.N. Nguyen, M. Benlabed, W.A. Buurman, J.-L. Vincent, Am. J. Physiol. 266, H1746–H1754 (1994).

    CAS  Google Scholar 

  10. J.A. Leff, C.P. Wilke, B.M. Hybertson, P.F. Shanley, CJ. Beehler, J.E. Repine, Am. J. Physiol. 265, L501–L506 (1993).

    CAS  Google Scholar 

  11. I.R. Hutcheson, B.J.R. Whittle, N.K. Boughton-Smith, Br. J. Pharmacol. 101, 815–820 (1990).

    Article  CAS  Google Scholar 

  12. S.I. Myers, R. Hernadez, A. Castaneda, Cardiovasc. Surg. 3, 207–210 (1995).

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Service de Réanimation Médicale, Hôpital Central, 54035, Nancy Cedex, France

    Ph. Bauer & A. Larcan

  2. Laboratoire de Biochimie, Hôpital Central, 54035, Nancy Cedex, France

    F. Belleville-Nabet, F. Dubois, B. Dousset & P. Nabet

  3. Laboratoire de Néphrologie, Faculté de Médecine, 54500, Vandoeuvre, France

    E. Vauthier, C. Colin & J. P. Mallié

  4. Laboratoire d’Anatomo-Pathologie, Faculté de Médecine, 54500, Vandoeuvre, France

    J. C. Guédenet

  5. Département D’information Médicale, Hôpital Central, 54035, Nancy Cedex, France

    O. Bodenreider

Authors
  1. Ph. Bauer
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  2. F. Belleville-Nabet
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  3. E. Vauthier
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  4. C. Colin
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  5. F. Dubois
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  6. J. C. Guédenet
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  7. O. Bodenreider
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  8. B. Dousset
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  9. P. Nabet
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  10. J. P. Mallié
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  11. A. Larcan
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Editor information

Editors and Affiliations

  1. Free University of Brussels, Brussels, Belgium

    Jean Nève

  2. Lariboisière Hospital, Paris, France

    Philippe Chappuis

  3. National Institute for Agronomic Research, Theix, France

    Michel Lamand

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© 1996 Springer Science+Business Media New York

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Bauer, P. et al. (1996). Metabolism of Selenium in a Model of Mesenteric Ischemia-Reperfusion Injury. In: Nève, J., Chappuis, P., Lamand, M. (eds) Therapeutic Uses of Trace Elements. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0167-5_39

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  • DOI: https://doi.org/10.1007/978-1-4899-0167-5_39

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-0169-9

  • Online ISBN: 978-1-4899-0167-5

  • eBook Packages: Springer Book Archive

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