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Therapeutic Uses of Trace Elements pp 219–224Cite as

Selenium as a Pharmacological Agent against Heavy Metal Poisoning and Chemical or Physical Carcinogenesis

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Abstract

Selenium (Se) is an essential trace element and a constituent of two enzymes, glutathione peroxidase (GPx) and type I iodothyronine 5’-deiodinase. GPx is a component of the antioxidant defense system and therefore plays an important role in the detoxification of xenobiotic-induced free radicals. However, most studies assessing the beneficial role of Se against xenobiotics have been conducted in Se-deficient animals. In these models, Se supplementation at nutritional doses restored normal selenium status, so that the effects eventually observed were attributed to a restoration of GPx activity. Other mechanisms may also be involved when higher Se doses are given. This review will focus on the effects of pharmacological doses of Se given to Se-adequate animals. Other reviews of nutritional and epidemiological studies are already available (1–5).

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References

  1. G.F. Combs, S.B. Combs, Pharmacol. Ther. 33, 303–315 (1987).

    Article  CAS  Google Scholar 

  2. J.T. Salonen, Ann. Clin. Res. 18, 18–21 (1986).

    Google Scholar 

  3. G.N. Schrauzer, Biol. Trace Elem Res. 33, 51–62 (1992).

    Article  CAS  Google Scholar 

  4. M. Garland, M.J. Stampfer, W.C. Willet, D.J. Hunter, in Natural antioxidants in human health and disease, pp. 263-286(1994).

    Google Scholar 

  5. A. Favier, in Les oligoéléments en nutrition et en thérapeutique, P. Chappuis, A. Favier (Eds), Lavoisier Tec&Doc, Paris, pp. 135–151(1995).

    Google Scholar 

  6. A.B. Kar, PR. Das, B. Mukerji, Proc. Natl. Inst. Sci. India 26B, 40–50 (1960).

    Google Scholar 

  7. J. Parizek, I. Ostadalova, Experientia 23, 142–143 (1967).

    Article  CAS  Google Scholar 

  8. V. Eybl, J. Sykora, F. Mertl, Arch. Toxikol 25, 296–305 (1969).

    Article  CAS  Google Scholar 

  9. A.E. Moffitt Jr, J.J. Clary, Res. Commun. Chem. Pathol. Pharmacol. 7, 593-(1974).

    CAS  Google Scholar 

  10. P. Kristensen, J.C. Hansen, Toxicology 12, 101–109 (1979).

    Article  CAS  Google Scholar 

  11. P. Kristensen, J.C. Hansen, Toxicology 16, 39–47 (1980).

    Article  CAS  Google Scholar 

  12. L. Magos, T.W. Clarkson, S. Sparrow, A.R. Hudson, Arch. Toxicol. 60, 422–426 (1987).

    Article  CAS  Google Scholar 

  13. L. Magos, T.W. Clarkson, A.R. Hudson, Environm. Ther. 228, 478–482 (1984).

    CAS  Google Scholar 

  14. O. Andersen, J.B. Nielsen, Environ. Health Perspect. 102 suppl. 3, 321–324 (1994).

    CAS  Google Scholar 

  15. J.B. Nielsen, O. Andersen, J. Trace Elem. Electrolytes Health Dis. 5, 245–250 (1991).

    CAS  Google Scholar 

  16. A. Naganuma, Y. Ishi, N. Imura, Ecotox. Environ. Safety 8, 572–580 (1984).

    Article  CAS  Google Scholar 

  17. L. Kosta, A.R. Byrne, V. Zelenko, Nature 254, 238–239 (1975).

    Article  CAS  Google Scholar 

  18. M. Nylander, J. Weiner, Br. J. Ind. Med. 48, 729–734 (1991).

    CAS  Google Scholar 

  19. L. Magos, M. Webb, CRC Critical Reviews in Toxicology 8, 1–42 (1980).

    Article  CAS  Google Scholar 

  20. S. Cavalli, N. Cardellicchio, J. Chromatogr. A 706, 429–436 (1995).

    Article  CAS  Google Scholar 

  21. R.A. Goyer, Am. J. Clin. Nutr. 61 suppl., 646S–650S (1995).

    CAS  Google Scholar 

  22. E. Komsta-Szumska, J. Chmielnicka, J.K. Piotrowski, Biochem. Pharmacol. 25, 2539–2540 (1976).

    Article  CAS  Google Scholar 

  23. J. Chmielnicka, E.A. Brzeznicka, Bull. Environ. Contam. Toxicol. 19, 183–190 (1978).

    Article  CAS  Google Scholar 

  24. J. Chmielnicka, E.A. Brzeznicka, A. Sniady, Arch. Toxicol. 59, 16–20 (1986).

    Article  CAS  Google Scholar 

  25. A.W. Glynn, N-G. Ilbäck, D. Brabencova, L. Carlsson, E-C. Enqvist, E. Netzel, A. Oskarsson, Biol. Trace Elem. Res. 39, 91–107 (1993).

    Article  CAS  Google Scholar 

  26. E.A. Brzeznicka, J. Chmielnicka, Environ. Health Perspect. 39, 131–142 (1981).

    CAS  Google Scholar 

  27. E.A. Brzeznicka, J. Chmielnicka, Environ. Health Perspect. 60, 423–431 (1985).

    CAS  Google Scholar 

  28. R.J. Niewenhuis, P.L. Fende, Biol. Reprod. 19, 1–7 (1978).

    Article  CAS  Google Scholar 

  29. H. Ohta, Ada Scholae Med. Univ. Gifu 33, 931–946 (1985).

    CAS  Google Scholar 

  30. H. Ohta, S. Imamiya, Kitasato Arch. Exp. Med. 59, 27–36 (1986).

    CAS  Google Scholar 

  31. Z.Z. Wahba, T.P. Coogan, S.W. Rhodes, M.P. Waalkes, J. Toxicol. Environ. Health 38, 171–182 (1993).

    Article  CAS  Google Scholar 

  32. B. Wlodarczyk, B. Biernacki, M. Minta, W. Kozaczynski, T. Juszkiewicz, Bull. Environ. Contam. Toxicol. 54, 907–912 (1995)

    Article  CAS  Google Scholar 

  33. M. Sidhu, M. Sharma, M. Bhatia, Y.C. Awasthi, R. Nath, Toxicology 83, 203–213 (1993).

    Article  CAS  Google Scholar 

  34. T.A. Gasiewicz, J.C. Smith, Biochim. Biophys. Acta 4281, 113–122 (1976).

    Article  Google Scholar 

  35. R.W. Chen, P.D. Whanger, P.H. Weswig, Bioinorg. Chem. 4, 125–133 (1975).

    Article  CAS  Google Scholar 

  36. S.C. Rastogi, J. Clausen, K.C. Srivastava, Toxicology 6, 377–388 (1976).

    Article  CAS  Google Scholar 

  37. F.L. Cerklewski, R.M. Forbes, J. Nutr. 106, 778–783 (1976).

    CAS  Google Scholar 

  38. B. Nehru, A. Iyer, J. Environ. Pathol. Toxicol. Oncol. 13, 265–268 (1994).

    CAS  Google Scholar 

  39. S.J.S. Flora, S. Singh, S.K. Tandon, Acta Pharmacol. Toxicol. 53, 28–32 (1983).

    Article  CAS  Google Scholar 

  40. J.P. Berry, P. Galle, J. Submicrosc. Cytol. Pathol. 26, 203–210 (1994).

    CAS  Google Scholar 

  41. A. Naganuma, M. Satoh, M. Yokoyama, N. Imura, Res. Commun. Chem. Pathol. Pharmacol. 42, 127–134 (1983).

    CAS  Google Scholar 

  42. J.P. Berry, C. Pauwells, S. Tlouzeau, G. Lespinats, Cancer Res. 44, 2864–2868 (1983).

    Google Scholar 

  43. K. Ohkawa, Y. Tsukada, H. Dohzono, K. Koike, Y. Terashima, Br. J. Cancer 58, 38–41 (1988).

    Article  CAS  Google Scholar 

  44. G. S. Baldew, C.J.A. van den Hamer, G. Los, N.P.E. Vermeulen, J.J.M. de Goeij, J.G. Mc Vie, Cancer Res. 49,3020–3023(1989)

    CAS  Google Scholar 

  45. G. S. Baldew, J.G.J. Mol, F.JJ. de Kanter, B. van Baar, J.J.M. de Goeij, N.P.E. Vermeulen, Biochem. Pharmacol. 41, 1429–1437(1991)

    Article  CAS  Google Scholar 

  46. J. Poupon, P. Chappuis, in Trace Elements and Free Radicals in Oxidative Diseases, A. E. Favier, J. Nève, P. Faure, eds., AOCS Press. Champaign, Illinois, pp. 261–275 (1994).

    Chapter  Google Scholar 

  47. C. Borek, A. Ong, H. Mason, L. Donahue, J.E. Biaglow, Proc. Natl. Acad. Sci. USA 83, 1490–1494 (1986).

    Article  CAS  Google Scholar 

  48. P.D. Whanger, Fundam. Appl. Toxicol. 3, 424–430 (1983).

    Article  CAS  Google Scholar 

  49. H.W. Lane, D. Medina, L.G. Wolfe, In Vivo 3, 151–160 (1989).

    CAS  Google Scholar 

  50. G. Hocman, Int. J. Biochem. 20, 123–132 (1988).

    Article  CAS  Google Scholar 

  51. C. Ip, Ann. Clin. Res. 18, 22–29 (1986).

    CAS  Google Scholar 

  52. B.S. Reddy, S. Sugie, H. Maruyama, P. Marra, Cancer Res. 48, 1777–1780 (1988).

    CAS  Google Scholar 

  53. K. El-Bayoumy, Carcinogenesis 15, 2395–2420 (1994).

    Article  CAS  Google Scholar 

  54. P. Prasanna, M. Jacobs, S. Yang, Mutation Res. 190, 101–105 (1984).

    Article  Google Scholar 

  55. A. Francis, T. Sherry, R. Bhattacharya, Mutation Res. 199, 85–93 (1988).

    CAS  Google Scholar 

  56. C.Y Shi, Y.C. Hew, C.N. Ong, Hum. Exp. Toxicol. 14, 55–60 (1995).

    Article  CAS  Google Scholar 

  57. H.M. Shen, C.N. Ong, B.L. Lee, C.Y. Shi, Carcinogenesis 16, 419–422 (1995).

    Article  CAS  Google Scholar 

  58. T.J. McGarrity, L.P. Peiffer, Carcinogenesis 14, 2335–2340 (1993).

    Article  CAS  Google Scholar 

  59. E.B. Thorling, K. Overvad, P. Bjerring, Acta Path. Microbiol. Immunol. Scand. A 91, 81–83 (1983).

    CAS  Google Scholar 

  60. R. Cadi, J.C. Beani, S. Belanger, M.J. Richard, A. Richard, A. Favier, P. Amblard, Nouv. Derm. 10, 266–272 (1991).

    Google Scholar 

  61. B.C. Pence, E. Delver, D.M. Dunn, J. Invest. Dermatol. 102, 759–761 (1994).

    Article  CAS  Google Scholar 

  62. M.T. Leccia, M.J. Richard, J.C. Beani, H. Faure, A.M. Monjo, J. Cadet, P. Amblard, A. Favier, Photochem. Photobiol. 58, 548–553 (1993).

    Article  CAS  Google Scholar 

  63. J.F. Weiss, V. Srinivasan, K.S. Kumar, M.R. Landauer, M.L. Patchen, in Trace Elements and Free Radicals in Oxidative Diseases, A.E. Favier, J. Nève, P. Faure, eds., AOCS Press, Champaign, Illinois, pp. 211–222 (1994).

    Google Scholar 

  64. P. Bienvenu, F. Herodin, M. Fatome, J.F. Kergonou, in Selenium in Medicine and Biology, J. Nève, A. Favier, eds., De Gruyter, Berlin, pp. 129–132 (1988).

    Google Scholar 

  65. H.S. Zackheim, K.K. Fu, A.S. Chan, Cancer Lett. 70, 123–127 (1993).

    Article  CAS  Google Scholar 

  66. J. Nayini, K. El-Bayoumi, S. Sugie, L.A. Cohen, B.S. Reddy, Carcinogenesis 10, 509–512 (1989).

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Laboratoire Central de Biochimie, Hôpital Lariboisière, Paris, France

    J. Poupon

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  1. J. Poupon
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Editors and Affiliations

  1. Free University of Brussels, Brussels, Belgium

    Jean Nève

  2. Lariboisière Hospital, Paris, France

    Philippe Chappuis

  3. National Institute for Agronomic Research, Theix, France

    Michel Lamand

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© 1996 Springer Science+Business Media New York

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Poupon, J. (1996). Selenium as a Pharmacological Agent against Heavy Metal Poisoning and Chemical or Physical Carcinogenesis. In: Nève, J., Chappuis, P., Lamand, M. (eds) Therapeutic Uses of Trace Elements. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0167-5_37

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  • DOI: https://doi.org/10.1007/978-1-4899-0167-5_37

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-0169-9

  • Online ISBN: 978-1-4899-0167-5

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